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Proteogenomics for pediatric brain cancer

by MARGARET SIMONIAN^*

University of Californian Los Angeles, David Geffen School of Medicine, Los Angeles, 90095, USA

* Corresponding Author: MARGARET SIMONIAN. Email:

BIOCELL 2021, 45(6), 1459-1463. https://doi.org/10.32604/biocell.2021.017369

Received 05 May 2021; Accepted 11 June 2021; Issue published 01 September 2021

Abstract

Pediatric central nervous system tumors are the most common tumors in children, it constitute 15%–20% of all malignancies in children and are the leading cause of cancer related deaths in children. Proteogenomics is an emerging field of biological research that utilizes a combination of proteomics, genomics, and transcriptomics to aid in the discovery and identification of biomarkers for diagnosis and therapeutic purposes. Integrative proteogenomics analysis of pediatric tumors identified underlying biological processes and potential treatments as well as the functional effects of somatic mutations and copy number variation driving tumorigenesis.

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