Open Access

ARTICLE

Immune prognostic implications of PSMD14 and its associated genes signatures in hepatocellular carcinoma

by CHUAN TIAN¹, MUBALAKE ABUDOUREYIMU¹, XINRONG LIN¹, HAO ZHOU², XIAOYUAN CHU¹, RUI WANG^1,*

1 Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210008, China
2 Department of Medical Oncology, Jinling Hospital, Nanjing Medical University, Nanjing, 210008, China

* Corresponding Author: RUI WANG. Email:

(This article belongs to the Special Issue: Decoding Gene (including circRNA, lincRNA miRNA and mRNA) Expression)

BIOCELL 2021, 45(6), 1527-1541. https://doi.org/10.32604/biocell.2021.016203

Received 17 February 2021; Accepted 06 May 2021; Issue published 01 September 2021

Abstract

PSMD14 played a vital role in initiation and progression of hepatocellular carcinoma (HCC). However, PSMD14 and its-related genes for the immune prognostic implications of HCC patients have rarely been analyzed. Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) database-Liver Hepatocellular Carcinoma (LIHC). Additionally, we used multi-dimensional bioinformatics analysis to construct and validate a PSMD14-based immune prognostic signature (including RBM45, PSMD1, OLA1, CCT6A, LCAT and IVD) for HCC prognosis prediction. Patients in the high-risk group shown significantly poorer survival than patients in the low-risk group. Calibration curves confirmed the good consistency between the clinical nomogram prediction and the actual observation. Gene set enrichment analyses (GSEA) revealed several significantly enriched pathways, which might help explain the underlying mechanisms. Besides, the rt-PCR further validates the expression of seven immune genes in HCC cells. Our study identified a novel PSMD14-based signature for HCC prognosis prediction, it provided new potential prognostic biomarkers and therapeutic targets for immunotherapy of HCC.

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Keywords

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