Open Access

ARTICLE

Exendin-4 inhibits the survival and invasiveness of two colorectal cancer cell lines via suppressing GS3Kβ/β-catenin/NF-κB axis through activating SIRT1

ATTALLA F. EL-KOTT^1,2,*, AYMAN E. EL-KENAWY³, EMAN R. ELBEALY⁴, ALI S. ALSHEHRI¹, HEBA S. KHALIFA², MASHAEL MOHAMMED BIN-MEFERIJ⁵, EHAB E. MASSOUD^6,7,8, AMIRA M. ALRAMLAWY⁹

1 Biology Department, College of Science, King Khalid University, Abha, 61413, Saudi Arabia
2 Zoology Department, College of Science, Damanhour University, Damanhour, 22511, Egypt
3 Pathology Department, College of Medicine, Taif University, Taif, 11099, Saudi Arabia
4 Biology Department, College of Science for Girls, King Khalid University, Abha, 61413, Saudi Arabia
5 Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 84428, Saudi Arabia
6 Biology Department, Faculty of Science and Arts, Dahran Aljnoub, King Khalid University, Abha, 61413, Saudi Arabia
7 Research Center for Advanced Materials Science, King Khalid University, Abha, 61413, Saudi Arabia
8 Agriculture Research Centre, Soil, Water and Environment Research Institute, Giza, 12619, Egypt
9 Mansoura Research Centre for Cord Stem Cell (MARC-CSC), Stem Cells Bank, Children’s Hospital, Mansoura University, Mansoura, 35516, Egypt

* Address correspondence to: Attalla F. El-Kott,