Open Access
ARTICLE
SENEX gene promotes cell proliferation by activating RB/E2F pathway in diffuse large B-cell lymphoma cells
JIYU WANG#, YING PAN#, YANG WAN, ZHIXIANG WANYAN, ZHITAO WANG, QIANSHAN TAO, ZHIMIN ZHAI*
Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, 230601, China
* Address correspondence to: Zhimin Zhai,
# These two authors contributed equally to this study
BIOCELL 2021, 45(4), 933-942. https://doi.org/10.32604/biocell.2021.014280
Received 15 September 2020; Accepted 18 January 2021; Issue published 22 April 2021
Abstract
The present study aimed to clarify the role of
SENEX in malignant cell proliferation in diffuse large B-cell
lymphoma (DLBCL). 22 DLBCL patients (6 newly diagnosed cases, 7 cases at complete remission, and 9 relapsed
cases) were included in the study. Our results indicated that both
SENEX gene and protein were significantly
increased in peripheral blood mononuclear cells (PBMCs) and tumor cells of relapsed DLBCL patients, accompanied
by overexpression of p21, p16, and phosphorylated retinoblastoma (Rb). Silencing the
SENEX gene in a DLBCL cell
line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1 phase.
Phosphorylated Rb and E2F1 were also decreased, and activation of the Rb/E2F1 pathway was obviously suppressed.
To conclude, the
SENEX gene promotes proliferation in PBMC and tumor cells of DLBCL patients by activating the
Rb/E2F1 pathway, in a manner suggesting that increased
SENEX expression affects the relapse of DLBCL and may
serve as an important target for DLBCL therapy.
Keywords
Cite This Article
APA Style
WANG, J., PAN, Y., WAN, Y., WANYAN, Z., WANG, Z. et al. (2021). senex gene promotes cell proliferation by activating RB/E2F pathway in diffuse large b-cell lymphoma cells. BIOCELL, 45(4), 933-942. https://doi.org/10.32604/biocell.2021.014280
Vancouver Style
WANG J, PAN Y, WAN Y, WANYAN Z, WANG Z, TAO Q, et al. senex gene promotes cell proliferation by activating RB/E2F pathway in diffuse large b-cell lymphoma cells. BIOCELL . 2021;45(4):933-942 https://doi.org/10.32604/biocell.2021.014280
IEEE Style
J. WANG et al., "SENEX gene promotes cell proliferation by activating RB/E2F pathway in diffuse large B-cell lymphoma cells," BIOCELL , vol. 45, no. 4, pp. 933-942. 2021. https://doi.org/10.32604/biocell.2021.014280