Open Access
REVIEW
HAORAN SU1, KEXIN LI1, XIAO LIU1,*, JING DU1, LI WANG4, XIAOYAN DENG3,*, YUBO FAN1,2,*
BIOCELL, Vol.45, No.4, pp. 797-811, 2021, DOI:10.32604/biocell.2021.014900
（This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases)
Abstract Endothelial cells arranged on the vessel lumen are constantly stimulated by blood flow, blood pressure and pressureinduced cyclic stretch. These stimuli are sensed through mechanical sensory structures and converted into a series of
functional responses through mechanotransduction pathways. The process will eventually affect vascular health. Therefore,
there has been an urgent need to establish in vitro endothelial biomechanics and mechanobiology of models, which
reproduce three-dimensional structure vascular system. In recent years, the rapid development in microfluidic technology
makes it possible to replicate the key structural and functionally biomechanical characteristics of vessels. Here, we
summarized the progress of microfluidic chips used… More >
Open Access
REVIEW
SUSANA PUNTARULO1,2, PAULA MARIELA GONZÁLEZ1,2,*
BIOCELL, Vol.45, No.4, pp. 813-821, 2021, DOI:10.32604/biocell.2021.015360
（This article belongs to this Special Issue: Oxidative Stress in Aquatic Organisms)
Abstract Environmental climate conditions could lead to an increasing global occurrence of microorganism blooms that
synthesize toxins in the aquatic environments. These blooms could result in significantly toxic events. Responses of
photosynthetic organisms to adverse environmental conditions implicate reactive oxygen species generation; but, due
to the presence of a varied cellular antioxidant defense system and complex signaling networks, this oxidative stress
could act as an important factor in the environmental adaptive processes. The objective of this review was to assess
how some biotoxins are implicated in the generation of oxidative and nitrosative metabolic changes, not only in
biotoxin-producing organisms but also… More >
Open Access
REVIEW
LIN LIU, ZHOUWEN XU, YUYAN JIANG, MD REZAUL KARIM, XIAO HUANG*
BIOCELL, Vol.45, No.4, pp. 823-833, 2021, DOI:10.32604/biocell.2021.013864
（This article belongs to this Special Issue: Kinesin Motors and Cell Cycle)
Abstract Protruded from cytomembrane, primary cilium is a widespread cell organelle that can be found in almost all cell
types in Mammalia. Because of its comprehensive requirement in various cellular activities and various functions in
different organs, primary cilium has been a valuable research area of human pathology research since the turn of the
millennium. And the potential application of the interaction between primary cilia and cell cycle regulation may be
the most promising direction as many primary cilium-caused diseases are found to be caused by cell cycle
dysregulation resulted from primary cilia defects. Therefore, a deep understanding of the interaction… More >
Open Access
REVIEW
JIAHE GUO2,#, XIAOGUANG JI3,#, YONGJIANG MAO2, ZHANGPING YANG2, ZHI CHEN2, YUAN YUAN1,*
BIOCELL, Vol.45, No.4, pp. 835-847, 2021, DOI:10.32604/biocell.2021.015652
（This article belongs to this Special Issue: Decoding Gene (including circRNA, lincRNA miRNA and mRNA) Expression)
Abstract Goat milk is widely recognized for its nutritional value. Fatty acid synthase (FAS) is the crucial enzyme of fatty acid de novo synthesis. It plays an important role in the formation of goat milk fat. In this paper, we first introduced the molecular regulation process of goat milk fat metabolism based on the structure research of FAS. Secondly, we reviewed some key factors in FAS transcription and post-transcriptional regulation of the goat mammary gland and preliminarily constructed the expression network of the goat mammary gland FAS gene. The purpose of this paper is to systematically introduce the role of FAS… More >
Open Access
REVIEW
ALFONSO BLÁZQUEZ-CASTRO1,2,*, JUAN CARLOS STOCKERT2,3
BIOCELL, Vol.45, No.4, pp. 849-862, 2021, DOI:10.32604/biocell.2021.015900
Abstract Melanins (eumelanin, pheomelanin, and allomelanin) represent a very, if not the most, important group of biological
pigments. Their biological roles are multiple, from photoprotection to antioxidant activity, heavy metal disposal or the myriad
uses of color in organisms across all Phyla. In the first part of this review, eumelanin biology and some chemical aspects will be
presented, as well as key physico-chemical features that make this biological pigment so interesting. The principal
characteristics of the melanocyte, the melanin-synthesizing cell in mammals, will also be introduced. Transformed
melanocytes are the cause of one of the most devastating known cancers: the malignant… More >
Open Access
REVIEW
SAYEQUA DANDOTI*
BIOCELL, Vol.45, No.4, pp. 863-884, 2021, DOI:10.32604/biocell.2021.013993
Abstract Inactivation of apoptosis is the prime phenomenon in cancer development and cancer treatments. Mutations in
the apoptotic pathway not only exert resistance to apoptosis and provide a survival advantage to cancer cells but also
confer resistance to cancer therapies. Escaping apoptosis is the “hallmark” of cancer cells. Cancer cells can withstand
many apoptotic stimuli, such as DNA damage, unfavorable environments, and cytotoxic therapies. Substantial
research has been carried out and is in good progress on the various mechanisms adopted by cancer cells to evade
apoptosis. This article reviews the apoptosis escape mechanisms by cancer cells, viz. apoptotic gene alterations (in… More >
Open Access
ARTICLE
WENBIAO CHEN, KEFAN BI, JINGJING JIANG, XUJUN ZHANG, HONGYAN DIAO*
BIOCELL, Vol.45, No.4, pp. 885-899, 2021, DOI:10.32604/biocell.2021.012938
Abstract The genome characteristics and structural functions of coding proteins correlate with the genetic diversity of
the H1N1 virus, which aids in the understanding of its underlying pathogenic mechanism. In this study, analyses of the
characteristic of the H1N1 virus infection-related genes, their biological functions, and infection-related reversal drugs
were performed. Additionally, we used multi-dimensional bioinformatics analysis to identify the key genes and then
used these to construct a diagnostic model for the H1N1 virus infection. There was a total of 169 differently expressed
genes in the samples between 21 h before infection and 77 h after infection. They were used… More >
Open Access
ARTICLE
WEIGAO ZHONG1,*, AIQIN CHEN2, XIAOHONG TANG1, YI LIU1
BIOCELL, Vol.45, No.4, pp. 901-910, 2021, DOI:10.32604/biocell.2021.08672
Abstract Earlier studies indicated that circular RNAs (circRNAs) were found in various cancer cells, and circFOXM1 was reported to act as an oncogene in non-small cell lung cancer (NSCLC). However, the function of circFOXM1 in NSCLC remains unclear. The expression levels of genes were measured using quantitative real-time polymerase chain reactions (qRT-PCR). Cell proliferation and apoptosis were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide solution (MTT) and flow cytometry assay. The relative protein expression was assessed by western blot. Moreover, transwell assays were employed to examine cell migration and invasion. The targeted relationship was confirmed by dual-luciferase reporter assay. The expression of circFOXM1 was… More >
Open Access
ARTICLE
MENGYI TANG1,2,3,4,#, BOWEN YANG1,2,3,4,#, CHUANG ZHANG1,2,3,4, CHAOXU ZHANG1,2,3,4, DAN ZANG1,2,3,4, LIBAO GONG1,2,3,4, YUNPENG LIU1,2,3,4, ZHI LI1,2,3,4,*, XIUJUAN QU1,2,3,4,*
BIOCELL, Vol.45, No.4, pp. 911-921, 2021, DOI:10.32604/biocell.2021.010119
Abstract Distal gastric cancer (DGC) is a subgroup of gastric cancer (GC), which has different molecular characteristics
from proximal gastric cancer (PGC). These differences result in different overall survival (OS) rates; however, data
pertaining to the survival rate in PGC or DGC are contradictory. This suggests that the location of GC is not the
unique cause of the different survival rates, while the molecular characteristics might be more important factors
determining the prognosis of DGC. Therefore, the aim of this study was to discover key prognostic factors in DGC
using bioinformatic methods and to explore the potential molecular mechanism. The Cancer… More >
Open Access
ARTICLE
XI YANG1, KE MA1,*, RUI CHEN1, NAIYI ZHANG2, YITING MENG3, JIA WEN1, QINPING LIAO1
BIOCELL, Vol.45, No.4, pp. 923-932, 2021, DOI: 10.32604/biocell.2021.013625
Abstract The current study is designed to evaluate certain immunocytochemical (ICC) biomarkers to gain a better
cytodiagnosis. For this purpose, 85 patients from March 2016 to March 2019 who planned to get a hysteroscopy assay
were recruited. Cytological sampling was conducted by scratching the uterus cavity using SAP-1, and the samples were
processed as liquid-based smears, using SurePath technology. 36 patients diagnosed with EC or atypical endometrial
hyperplasia were recruited in this study. 33 cases were diagnosed with EC, and 3 cases were diagnosed with atypical
endometrial hyperplasia, allocated with EC or precancerous lesions group. 26 cases were diagnosed with benign… More >
Open Access
ARTICLE
JIYU WANG#, YING PAN#, YANG WAN, ZHIXIANG WANYAN, ZHITAO WANG, QIANSHAN TAO, ZHIMIN ZHAI*
BIOCELL, Vol.45, No.4, pp. 933-942, 2021, DOI:10.32604/biocell.2021.014280
Abstract The present study aimed to clarify the role of SENEX in malignant cell proliferation in diffuse large B-cell
lymphoma (DLBCL). 22 DLBCL patients (6 newly diagnosed cases, 7 cases at complete remission, and 9 relapsed
cases) were included in the study. Our results indicated that both SENEX gene and protein were significantly
increased in peripheral blood mononuclear cells (PBMCs) and tumor cells of relapsed DLBCL patients, accompanied
by overexpression of p21, p16, and phosphorylated retinoblastoma (Rb). Silencing the SENEX gene in a DLBCL cell
line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1… More >
Open Access
ARTICLE
CHUNJIAO LIU1,2, QINHONG KONG1,2, FENG PAN1,2, SHAN JIANG1,2, LINGJIE MENG1,2, GAI HUANG1,2, LIDAN LU1,2, SANHUA LI1,2,*, YUN LIU1,2,3,*
BIOCELL, Vol.45, No.4, pp. 943-951, 2021, DOI:10.32604/biocell.2021.015836
Abstract Traditional Chinese medicine (TCM) has been increasingly applied in both preventing and treating a variety of
cancers in the last decades, attributing to its fewer side effects as compared with chemotherapy drugs. Hellebrigenin, a
component of Chanpi from the skin of Bufo bufogargarizans Cantor or Duttaphrynus melanostictus has been reported
to have an obvious anti-cancer activity on various cancers. However, the effect and mechanism of hellebrigenin on
colorectal cancers were still unknown. Herein, the present study demonstrated hellebrigenin significantly reduced
viability and triggered apoptosis via the intrinsic pathway in colorectal cancer cell lines HCT116 and HT29 in vitro
and in… More >
Open Access
ARTICLE
BIDYUT MALLICK1,#, ASHISH RANJAN SHARMA2,#, MANOJIT BHATTACHARYA3, SANG-SOO LEE1,*, CHIRANJIB CHAKRABORTY4,*
BIOCELL, Vol.45, No.4, pp. 953-961, 2021, DOI:10.32604/biocell.2021.015530
Abstract PPARγ is a peroxisome proliferator-activated receptor (PPAR) family protein and is a target for type 2 diabetes (T2D). In this paper, we have performed a molecular docking analysis between ligand molecules (CID9816265, CID11608015, CID20251380, CID20251343, CID20556263, CID624491, CID42609928, and CID86287562) and PPARγ to determine the ligand specificity. It also helps to understand the ligand-binding domain (LBD) activity of PPARγ during the binding of the ligand. Further, a molecular dynamics simulation study was performed to determine the ligand biding stability in the PPARγ LBD. Its ligand specificity informed us about the potentiality of selecting a partial agonist. The study also shows… More >
Open Access
ARTICLE
HAN NIU1,#, XIN CHEN1,#, XUEQI FU1, JINGTIAN ZHANG1, GUODONG LI4, YUXIANG WANG1, JIAYUE SONG1, XUETING MA1, CHEN HU5, XUEMIN XU3, FUQIANG ZHANG2,*, LINLIN ZENG1,*
BIOCELL, Vol.45, No.4, pp. 963-970, 2021, DOI:10.32604/biocell.2021.015297
Abstract Amyotrophic lateral syndrome (ALS) is a progressive degenerative disorder characterized by motor neuron death and axon degeneration. Mitochondrial dysfunction plays a key role in the pathogenesis of ALS, the mechanism of which remains poorly understood. The B-cell lymphoma-2 (Bcl-2) family of proteins that control and mediate mitochondrial function and apoptosis, including the pro-apoptotic members Bcl2-Associated X (Bax), are involved in ALS development. The death receptor 6 (DR6) regulates motor neuron death in ALS, and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6. Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced… More >
Open Access
ARTICLE
SHUANG-LI HAO, FEI-DA NI, BANG-HONG WEI, ZHEN-FANG LI, TONG YANG, WAN-XI YANG*
BIOCELL, Vol.45, No.4, pp. 971-984, 2021, DOI:10.32604/biocell.2021.015178
Abstract Spermatogenesis is a complicated and highly regulated male gamete differentiation process that begins with the proliferation and differentiation of spermatogonia to the release of the mature spermatozoa. The autophagy-related gene atg7 has been reported as closely related to spermatogenesis and communication of Sertoli cell-germ cells in mice, including acrosome biogenesis, sperm flagellum development, and ectoplasmic specialization assembly. However, the function of es-ATG7 and its molecular regulatory mechanism during spermatogenesis in Crustacea remain largely unknown. Here, we cloned and identified es-atg7 from the testes of the Chinese mitten crabs Eriocheir sinensis and found that the expression of es-atg7 was relatively high… More >
Open Access
ARTICLE
TING LI1,#, XINHUI SUN2,#, NANNAN LI1, HONGMIN GUO2,*
BIOCELL, Vol.45, No.4, pp. 985-994, 2021, DOI:10.32604/biocell.2021.012371
Abstract Fibroblast growth factors (FGFs) play pivotal roles in cell migration and proliferation. However, the identity of
the FGF that plays a dominant role in kidney cell proliferation remains unclear. Therefore, in this study, we investigated
the dominant FGF among all FGFs. To this end, RNA-sequencing, qRT-PCR, western blotting, and ChIP assays were
performed. FGF9 showed the highest expression among all FGFs, and its overexpression significantly promoted
proliferation in the mouse kidney cell line C57BL/6 and increased JNK and AKT phosphorylation levels. Further,
RNA-seq analysis identified 365 upregulated and 276 downregulated genes in FGF9-overexpressed cells. These
differentially expressed genes were classified… More >
Open Access
ARTICLE
HONGXIA HU*, PING GUO, QIAN ZHAO, HAORAN LI, HUALEI LIU, CAIHONG MA
BIOCELL, Vol.45, No.4, pp. 995-1004, 2021, DOI:10.32604/biocell.2021.012851
Abstract This study aims to detect the expression of selected circulating microRNAs (miRNA), including miRNA-451a,
miRNA-486-5p and miR-10b-5p, and their prospective roles as biomarkers in patients with atherosclerosis. For this
purpose, levels of miRNAs were detected by real-time quantitative polymerase chain reaction (RT-qPCR) in case (N =
30) and healthy control (N = 30) groups. Receiver operating characteristic (ROC) curve analysis was carried out to
evaluate the diagnostic ability of miRNAs. The correlations of miR-451a with lipid parameters were evaluated using
Pearson’s correlation coefficients. HUVEC tested by ox-LDL was used as a cellular model of atherosclerosis. Cell
viability and apoptosis were… More >
Open Access
ARTICLE
ZHIPING WEI1,2, YAJUN LIU1, MEIWEN YANG3, MENGDI LI1, KEXIN LI1, LUXI ZHENG1, HUIQIONG GUO1, FENFANG HONG4,*, SHULONG YANG1,*
BIOCELL, Vol.45, No.4, pp. 1005-1012, 2021, DOI:10.32604/biocell.2021.014581
Abstract Background and Objective: LTB4 has been shown to be involved in rheumatoid arthritis (RA) pathogenesis.
The effect of Dioscin(Dio) on the LTB4 pathway of RA have not been reported yet. This study aimed at further
exploring whether Dioscin’s effects on TNF-α induced collagen-induced arthritis (CIA) rat fibroblast-like synoviocytes
(FLS) connected with the LTB4 and its receptor pathway. Materials & Methods: In this experiment, control group,
TNF-α group, and different concentrations of Dioscin groups were established. Cell viability was evaluated using
MTT assay. The levels of LTB4 in the samples of above groups were measured using ELISA. The mRNA expression
levels… More >
Open Access
ARTICLE
LORENZO ALIBARDI1, BERND NOECKER2
BIOCELL, Vol.45, No.4, pp. 1013-1022, 2021, DOI:10.32604/biocell.2021.013913
Abstract The differentiation of cells composing mature human hairs produces layers with different corneous
characteristics that would tend to flake away one from another, as in the corneous layer of the epidermis, without
anchoring junctions. It is likely that cell junctions established in the forming cells of the hair bulb are not completely
degraded like in the corneous layer of the epidermis but instead remain in the hair shaft to bind mature cuticle,
cortex, and medulla cells into a compact hair shaft. During cell differentiation in hairs, cell junctions seem to
disappear, and little is known about the fate of junctional… More >
Open Access
ARTICLE
XINYAN CHEN1,2, HAIXIA ZHANG1,2, LIN LI1,2,*
BIOCELL, Vol.45, No.4, pp. 1023-1032, 2021, DOI:10.32604/biocell.2021.014873
（This article belongs to this Special Issue: Cellular Biomechanics in Health and Diseases)
Abstract Corneal collagen crosslinking (CXL) has revolutionized the treatment of keratoconus in the past decade. In
order to evaluate the 3-month effects of CXL on corneal fibroblasts, a longitudinal study at the tissue and cellular
level was carried out with a total of 16 rabbits that underwent CXL, deepithelialization (DEP), or non-treatment
(control) and kept for 1 to 3 months. The duration of corneal stromal remodeling after CXL was determined by
examining the differentiation, apoptosis, and number changes of keratocytes in tissue sections from animals 1, 2, or 3
months post-treatment. Upon the finish of tissue remodeling, separate rabbits were used… More >
Open Access
ARTICLE
JINGPENG ZHOU1,2,#, XIAOGUANG JI3,#, YUHAO WANG1,2, XIAOLONG WANG1,2, YONGJIANG MAO1,2,*, ZHANGPING YANG1,2,*
BIOCELL, Vol.45, No.4, pp. 1033-1044, 2021, DOI:10.32604/biocell.2021.015586
（This article belongs to this Special Issue: Decoding Gene (including circRNA, lincRNA miRNA and mRNA) Expression)
Abstract Cow mastitis is the most common disease that affects the dairy farming industry and causes serious harm to dairy cows and humans, and Staphylococcus (S.) aureus is one of the main pathogens that cause mastitis in dairy cows. In this study, a mastitis model was established through the infection of bovine mammary epithelial cells (BMECs) with S. aureus (bacterial concentration of 1 × 109/mL), and these cells and a blank group (untreated) were analyzed by flow cytometry (10000 cells, 200 cells collected per second), hematoxylin and eosin (H&E) staining and immunohistochemistry. In addition, the lncRNAs (long non-coding RNAs) in the… More >
Open Access
ARTICLE
HANXIANZHI XIAO, RONGJIA QI, ZILING WANG, MINGHE XIAO, YUE XIANG, YAPING WANG, LU WANG*
BIOCELL, Vol.45, No.4, pp. 1045-1058, 2021, DOI:10.32604/biocell.2021.015039
Abstract Chemotherapy may cause cellular oxidative stress to bone marrow. Oxidative damage of bone marrow
hematopoietic microenvironment is closely related to chronic myelosuppression after chemotherapeutic treatment.
Angelica sinensis polysaccharides (ASP) are major effective ingredients of traditional Chinese medicine Angelica with
multi-target anti-oxidative stress features. In the current study, we investigated the protective roles and mechanisms
of ASP on chemotherapy-induced bone marrow stromal cell (BMSC) damage. The human bone marrow stromal cell
line HS-5 cells were divided into control group, 5-FU group, 5-FU + ASP group, and 5-FU + LiCl group to
investigate the mechanism of ASP to alleviate 5-FU-induced BMSC proliferation… More >
Open Access
ARTICLE
YIBIN RUAN1, ZHONGMING XIE2, QIONG LIU2, LIXIAO ZHANG2, XIKUI HAN2, XIAOYAN LIAO2, JIAN LIU1,*, FENGGUANG GAO2,*
BIOCELL, Vol.45, No.4, pp. 1059-1067, 2021, DOI:10.32604/biocell.2021.015261
Abstract Nicotine and menthol, agonists of nicotinic acetylcholine receptor (nAChR) and transient receptor potential
melastatin type 8 (TRPM8), serve important roles in the prevention of cell death-involved neurodegenerative diseases.
However, the potential synergistic effects of nicotine and menthol on anti-apoptotic ability are still uncertain. In the
present study, the potential synergistic effects of nicotine and menthol on cisplatin or amyloid β1-42 induced cell
model of the neurodegenerative diseases were explored by assessing cell viability, TNF-α expression, caspase-3
activation, and the collapse of mitochondrial membrane potential in human SH-SY5Y neuroblastoma cells. Statistical
significance was tested using Student’s t-test or one-way ANOVA with… More >
Open Access
REVIEW
THARANGANI WELEGAMA1, MOHD Y. RAFII1,2,*, KHAIRULMAZMI AHMAD1,3, SHAIRUL I. RAMLEE1,2, YUSUFF OLADOSU1
BIOCELL, Vol.45, No.4, pp. 1069-1079, 2021, DOI:10.32604/biocell.2021.014354
Abstract Tomato (Solanum lycopersicum L.) belonging to the family Solanaceae is the second most consumed and
cultivated vegetable globally. Since the ancient time of its domestication, thousands of cultivated tomato varieties have
been developed targeting an array of aspects. Among which breeding for yield and yield-related traits are mostly
focused. Cultivated tomato is extremely genetically poor and hence it is a victim for several biotic and abiotic stresses.
Among the biotic stresses, the impact of viral diseases is critical all over tomato cultivating areas. Improvement of
tomato still largely rely on conventional methods worldwide while molecular approaches, particularly Marker Assisted
Selection… More >
Open Access
ARTICLE
MOHAMMAD FAIZAN1, AHMAD FARAZ2, SHAMSUL HAYAT3, JAVAID A. BHAT4,*, FANGYUAN YU1,*
BIOCELL, Vol.45, No.4, pp. 1081-1093, 2021, DOI:10.32604/biocell.2021.015363
（This article belongs to this Special Issue: Molecular and Cellular Nanobiotechnology)
Abstract Nanotechnology has greatly expanded the applications of nanoparticles (NPs) domain in the scientific field. In
this context, the zinc oxide nanoparticles (ZnO-NPs) and 24-epibrassinolide (EBL) has been revealed to positively
regulate plant metabolism and growth. In the present study, we investigated the role of ZnO-NPs and EBL in the
regulation of plant growth, photosynthetic efficiency, enzymes activities and fruit yield in tomato. Foliar treatment of
ZnO-NPs at three levels (10, 50 or 100 ppm) and EBL (10−8 M) were applied separately or in combination to the
foliage of plant at 35–39 days after sowing (DAS); and the control plants were… More >
Open Access
ARTICLE
HANNA AMOANIMAA-DEDE, JIACHENG ZHANG, CHUNTAO SU, HONGBO ZHU*
BIOCELL, Vol.45, No.4, pp. 1095-1105, 2021, DOI:10.32604/biocell.2021.015053
（This article belongs to this Special Issue: Advances in Plant Cell Biology Research)
Abstract Sweet potato is a multifunctional root crop with many essential nutrients and bioactive compounds. Due to its
genetic complexity and lack of genomic resources, efficient genetic studies and cultivar development lag far behind other
major crops. Simple sequence repeats (SSRs) offer an effective molecular marker technology for molecular-based breeding
and for locating important loci in crop plants, but only a few have previously been developed in sweet potato. To further
explore new SSR markers and accelerate their use in sweet potato genetic studies, genome-wide characterization and
development of SSR markers were performed using the recently published genome of sweet potato… More >
Open Access
ARTICLE
QICHAO WANG1, WUJING ZENG1, BASHARAT ALI2, XUEMIN ZHANG3, LING XU1,*, ZONGSUO LIANG1,*
BIOCELL, Vol.45, No.4, pp. 1107-1119, 2021, DOI:10.32604/biocell.2021.015282
Abstract Andrographis paniculata (A. paniculata) is a Chinese herbal medicine that clears away heat, reduces
inflammation, protects the liver, and promotes choleretics. The WRKYs of A. paniculata are still not well
characterized, although many WRKYs have been identified in various plant species. In the present study, 59 A.
paniculata WRKY (ApWRKY) genes were identified and renamed on the basis of their respective chromosome
distribution. These ApWRKYs were divided into three groups via phylogenetic analysis according to their WRKY
domains and combined with WRKY of Arabidopsis. The 59 identified ApWRKY transcription factors were nonuniformity distributed on 23 chromosomes of A. paniculata. From… More >
Open Access
ARTICLE
CHUNKUN FAN, YONGPENG ZHANG, CHUNBAO YANG, YAWEI TANG, JI QU, BU JIE, DEJI QUZHEN, LIYUN GAO*
BIOCELL, Vol.45, No.4, pp. 1121-1135, 2021, DOI:10.32604/biocell.2021.014336
Abstract Salinity is a serious challenge for agriculture production by limiting the arable land. Rice is a major staple food
crop but very sensitive to salt stress. In this study, we used Arabidopsis for the functional characterization of a rice F-box
gene LOC_Os04g48270 (OsPP12-A13) under salinity stress. OsPP12-A13 is a nuclear-localized protein that is strongly upregulated under salinity stress in rice and showed the highest expression in the stem, followed by roots and leaves. Two
types of transgenic lines for OsPP12-A13 were generated, including constitutive tissue over-expression using the
CaMV35S promoter and phloem specific over-expression using the pSUC2 promoter. Both types… More >
Open Access
ARTICLE
LINGJIAO FAN, CHENGYONG HE, MENGMENG WU, DEHANG GAO, ZHENFEI DONG, SHENGFAN HOU, ZEKUN FENG, HONGQING WANG*
BIOCELL, Vol.45, No.4, pp. 1137-1151, 2021, DOI:10.32604/biocell.2021.015396
Abstract Strawberry mottle virus (SMoV) is one of the most common viruses infecting strawberries, causing losses to
fruit yield and quality. In this study, 165 strawberry leaf samples were collected from six provinces of China, 46 of
which tested positive for SMoV. The complete genome sequences of 11 SMoV isolates were obtained from Liaoning
(DGHY3, DGHY16-2, DGHY17, DGHY20-2, DGHY21, DGHY26-2), Shandong (SDHY1, SDHY5, SDHY31-2,
SDHY33-2), and Beijing (BJMX7). The RNA1 and RNA2 nucleotide identities between the 11 Chinese isolates were
95.4–99.3% and 96.3–99.6%, respectively, and they shared 78.4–96.6% and 84.8–93.5% identities with the available
SMoV isolates in GenBank. Recombination analysis revealed… More >
Open Access
ARTICLE
LIYAN SU1,2,#, HONG YU3,#, JIUDONG ZHANG1, XIAOHONG ZHAO1, XUAN LIU1, QIANG LI1,4,*
BIOCELL, Vol.45, No.4, pp. 1153-1166, 2021, DOI:10.32604/biocell.2021.014499
Abstract Auxin signaling and its components (Auxin/Indole-3-Acetic Acid (Aux/IAA)) are critical for plant growth and
development. Here, we performed a genome-wide annotation and identified twenty-one Aux/IAA genes in strawberry
(Fragaria vesca). Most FveIAAs were located on chromosomes 1, 2, 4, 5, and 6, while no FveIAAs were found in
chromosomes 3 and 7. Phylogenetic analysis divided these genes into nine subfamilies. Most FveIAAs contained the
DNA-binding and Aux/IAA domains, as well as motifs I–IV. There were 2–6 exons in the FveIAA genes based on the
gene structure analysis. Also, we found that four pairs of FveIAA genes underwent segment duplications. Moreover,… More >
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