Open Access
REVIEW
Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?
AMYLLY SANUELLY DA PAZ MARTINS1, SAMARA BOMFIM GOMES CAMPOS2, MARÍLIA OLIVEIRA FONSECA GOULART1,2,3, FABIANA ANDRÉA MOURA4,*
1 Programa de Pós-Graduação da Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
2 Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
3 Programa de Pós-Graduação em Química e Biotecnologia (PPGQB/UFAL), Campus A. C. Simões, Avenida Lourival Melo Mota, s/n, Tabuleiro dos Martins, Maceió, AL 57072-970, Brazil
4 Programa de Pós-Graduação em Nutrição (PPGNU/UFAL), Programa de Pós-Graduação em Ciências Médicas (PPGCM/UFAL), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
* Address correspondence to: Fabiana Andréa Moura,
BIOCELL 2021, 45(3), 461-481. https://doi.org/10.32604/biocell.2021.014332
Received 17 September 2020; Accepted 20 November 2020; Issue published 03 March 2021
Abstract
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, has a not yet
completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative
stress and dysbiosis. Extraintestinal manifestations can occur and affect several organs, including the liver and bile
ducts, joints, skin, eyes, and less frequently, the heart, brain, and kidneys, increasing the risk of morbidity and
mortality. These repercussions may be associated with the activity or severity of IBD. The present review proposes to
report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal
manifestations, aiming to contribute to a better understanding of the disease and to focus on the development of
individualized preventive and therapeutic strategies.
Keywords
Cite This Article
SANUELLY, A., BOMFIM, S., OLIVEIRA, M., MOURA, F. A. (2021). Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?.
BIOCELL, 45(3), 461–481. https://doi.org/10.32604/biocell.2021.014332
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