Vol.45, No.3, 2021, pp.461-481, doi:10.32604/biocell.2021.014332
OPEN ACCESS
REVIEW
Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?
  • AMYLLY SANUELLY DA PAZ MARTINS1, SAMARA BOMFIM GOMES CAMPOS2, MARÍLIA OLIVEIRA FONSECA GOULART1,2,3, FABIANA ANDRÉA MOURA4,*
1 Programa de Pós-Graduação da Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
2 Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
3 Programa de Pós-Graduação em Química e Biotecnologia (PPGQB/UFAL), Campus A. C. Simões, Avenida Lourival Melo Mota, s/n, Tabuleiro dos Martins, Maceió, AL 57072-970, Brazil
4 Programa de Pós-Graduação em Nutrição (PPGNU/UFAL), Programa de Pós-Graduação em Ciências Médicas (PPGCM/UFAL), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
* Address correspondence to: Fabiana Andréa Moura,
Received 17 September 2020; Accepted 20 November 2020; Issue published 03 March 2021
Abstract
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and dysbiosis. Extraintestinal manifestations can occur and affect several organs, including the liver and bile ducts, joints, skin, eyes, and less frequently, the heart, brain, and kidneys, increasing the risk of morbidity and mortality. These repercussions may be associated with the activity or severity of IBD. The present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal manifestations, aiming to contribute to a better understanding of the disease and to focus on the development of individualized preventive and therapeutic strategies.
Keywords
Oxidative stress, Microbiota, Bacterial translocation, Ulcerative colitis, Crohn disease
Cite This Article
SANUELLY, A., BOMFIM, S., OLIVEIRA, M., MOURA, F. A. (2021). Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?. BIOCELL, 45(3), 461–481.
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