Open Access

REVIEW

A short review of the genes involved in the development and progression of colorectal cancer

by Amayna Zakaria, Syed Abdullah Ibn Asaduzzaman, Zobayda Nahar, Hafsa Jarin Snigdha, Taskina Murshed, Rashed Noor^*

Department of Life Sciences, School of Environment and Life Sciences, Independent University, Bangladesh (IUB), Dhaka, 1229, Bangladesh

* Address correspondence to: Rashed Noor,

BIOCELL 2021, 45(3), 483-487. https://doi.org/10.32604/biocell.2021.014704

Received 22 October 2020; Accepted 21 December 2020; Issue published 03 March 2021

Abstract

The extent and aggression of colorectal cancer is a worldwide public health threat. Extensive research has been conducted on the pre-requisites leading to this fatal cancer. An array of genes along with their mutations and the signal transduction pathways leading to the cellular transformation into the cancerous cells have been investigated. Based on the knowledge gained so far, present review shortly discussed the role of the major genes especially those are involved in instigating abnormalities in the cellular cycles, cellular proliferation and differentiation. A simple but novel molecular scheme of the colorectal cancer development has also been plotted.

---

Keywords

---