Open Access

ARTICLE

Study on the clinical significance of TRPV2 and MMP2 expressions in ovarian cancer

XIAOPANG REN^#, WANJIAO HAO^#, JIN LIU, YE LI, BING WANG, XINHUI ZU, HUILING XUE^*

Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding, 071000, China

* Address correspondence to: Huiling Xue,
# These authors contributed equally to this work

(This article belongs to the Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)

BIOCELL 2021, 45(3), 521-526. https://doi.org/10.32604/biocell.2021.012137

Received 26 June 2020; Accepted 30 September 2020; Issue published 03 March 2021

Abstract

Ovarian cancer was one of the most common malignant tumors in female reproductive organs. Moreover, epithelial ovarian cancer showed the highest mortality rate in gynecological tumors, posing serious threats to women’s life and health. Transient Receptor Potential Cation Channel Subfamily V Member 2 (TRPV2) and matrix metalloproteinase-2 MMP-2 have been found to play important roles in regulating the pathogenesis of most tumors, but there were few studies exploring the relationships of TRPV2 and MMP-2 in OC. Therefore, we evaluated the expression of TRPV2 and MMP-2 proteins in cancer tissues and adjacent normal tissues of OC patients. Immunohistochemistry was used to analyze the expressions of TRPV2 and MMP-2 in cancer tissues (N = 70) and adjacent normal tissues (N = 70) of OC patients, and the correlation of TRPV2 and MMP-2 with the occurrence and development of OC was analyzed with the combination of clinicopathological parameters of OC patients. The results showed that the expressions of TRPV2 and MMP-2 in OC tissues were significantly higher than those in adjacent normal tissues, and there were significant differences in TRPV2 and MMP-2 expressions in terms of tumor stage, differentiation, and lymph node metastasis of OC. Taken together, our results showed that protein expressions of TRPV2 and MMP-2 were closely related associated with the occurrence and development of OC.

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