Open Access

ARTICLE

Thymidylate synthase confers pemetrexed resistance of non-small cell lung cancer cells by EGFR/PI3K/AKT pathway

DAN ZHANG¹, HAIJING LIU¹, ZHENNAN YI², YUANYUAN LU³, YANYAN CHEN⁴, WEIQIANG SU², HUIBING LIN², ZHIHUI ZHANG^5,*, WEI LEI^6,*

1 Department of Oncology, Center People’s Hospital of Zhanjiang, Zhanjiang, 524000, China
2 Department of Respiration, Center People’s Hospital of Zhanjiang, Zhanjiang, 524000, China
3 Department of Oncology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu, 241001, China
4 Department of Oncology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China
5 Department of Thoracic Surgery, Center People’s Hospital of Zhanjiang, Zhanjiang, 524000, China
6 Cardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China

* Address correspondence to: Zhihui Zhang, ; Wei Lei,