Open Access

ARTICLE

CircRNA ATF6 promotes ovarian cancer cell progression by activating PTEN/mTOR signaling pathway

by Lieting Ma¹, Miaoling Li^2,*, Xinglong Zheng^3,*

1 Department of Laboratory Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China
2 Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China
3 Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China

* Address correspondence to: Miaoling Li, ; Xinglong Zheng,

BIOCELL 2021, 45(2), 317-321. https://doi.org/10.32604/biocell.2020.09313

Received 02 December 2019; Accepted 28 April 2020; Issue published 19 February 2021

Abstract

Ovarian cancer is a malignant cancer type and affects women’s lives in the world. Circular RNAs (circRNAs) have been involved with the progression of cancers. In our study, we are going to explore the functions of circATF6 in ovarian cancer. The qRT-PCR assay was used to detect expressions of genes. Actinomycin D and RNase R treatment were implemented to verify the circular RNA character of circATF6. Besides, Cell proliferation was assessed by colony formation assay and EdU assay. Silenced circATF6 could reduce the proliferation of ovarian cancer cells. In addition, inhibited circATF6 could promote the cell apoptosis and inhibit related proteins in PTEN/mTOR signaling pathway in ovarian cancer. In conclusion, CircRNA ATF6 promotes ovarian cancer cell progression by activating PTEN/ mTOR signaling pathway.

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Citations