Open Access

ARTICLE

CLEC3A gene three polymorphisms and risk of gastric cancer in Northwestern Chinese population

PING YANG, LIJUAN YUAN, SHUJIA PENG, YANMING DONG, LIN YANG, XI’E HU, GUOQIANG BAO^*

Department of General Surgery, Tangdu Hospital, Air Force Medical University of People’s Liberation Army, Xi’an, 710038, China

* Address correspondence to: Guoqiang Bao,

BIOCELL 2021, 45(1), 103-108. https://doi.org/10.32604/biocell.2021.011220

Received 27 April 2020; Accepted 19 August 2020; Issue published 26 January 2021

Abstract

This study aimed to evaluate the association between the CLEC3A gene polymorphisms (rs2735401/rs2293776/ rs2072665) and the gastric cancer risk in the Northwestern Chinese population. A hospital-based case-control study was conducted on 681 cases and 756 healthy controls. Odds ratio (OR) and 95% confidence intervals (CI) were applied to evaluate the association of the CLEC3A polymorphisms on gastric cancer risk. We found that there was no significant association between the CLEC3A polymorphisms and gastric cancer susceptibility, which was detected in the main analysis or stratification analyses of age, gender, and clinical stages. Our findings verified that the CLEC3A polymorphisms are not associated with gastric cancer susceptibility in the Northwestern Chinese population; other polymorphisms should be investigated to further clarify the susceptibility to gastric cancer.

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Keywords

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