TY - EJOU
AU - BURNETT, MERVIN
AU - RODOLICO, VITO
AU - SHEN, FAN
AU - LENG, ROGER
AU - ZHANG, MINGYONG
AU - EISENSTAT, DAVID D.
AU - SERGI, CONSOLATO
TI - PathVisio Analysis: An Application Targeting the miRNA Network Associated with the p53 Signaling Pathway in Osteosarcoma
T2 - BIOCELL
PY - 2021
VL - 45
IS - 1
SN - 1667-5746
AB - MicroRNAs (miRNAs) are small single-stranded, non-coding RNA molecules involved in the pathogenesis and
progression of cancer, including osteosarcoma. We aimed to clarify the pathways involving miRNAs using new
bioinformatics tools. We applied WikiPathways and PathVisio, two open-source platforms, to analyze miRNAs in
osteosarcoma using miRTar and ONCO.IO as integration tools. We found 1298 records of osteosarcoma papers
associated with the word “miRNA”. In osteosarcoma patients with good response to chemotherapy, miR-92a, miR-
99b, miR-193a-5p, and miR-422a expression is increased, while miR-132 is decreased. All identified miRNAs seem to
be centered on the TP53 network. This is the first application of PathVisio to determine miRNA pathways in
osteosarcoma. MiRNAs have the potential to become a useful diagnostic and prognostic tool in the management of
osteosarcoma. PathVisio is a full pathway editor with the potentiality to illustrate the biological events, augment
graphical elements, and elucidate all the physical structures and interactions with standard external database identifiers.
KW - MiRNA
KW - Osteosarcoma
KW - p53
KW - Carcinogenesis
KW - Oncology
KW - Cancer
KW - Bone tumor
KW - Bioinformatics
DO - 10.32604/biocell.2021.013973