Open Access

REVIEW

Nuclear regulation of mitochondrial functions during oocyte development

TIANQI WANG, WANXI YANG^*

The sperm laboratory, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China

* Address correspondence to: Wanxi Yang,

(This article belongs to the Special Issue: Kinesin Motors and Cell Cycle)

BIOCELL 2020, 44(4), 469-478. https://doi.org/10.32604/biocell.2020.014708

Received 22 October 2020; Accepted 06 November 2020; Issue published 24 December 2020

Abstract

Mitochondria are important in eukaryotic cells due to their functions in energy production and regulation over other cellular activities. Oocytes are produced by a long and precisely controlled process, the dysfunction of which leads to impaired female fertility. As oocytes mature, mitochondria are constantly under the regulation of nuclear genes, the process of which can be modulated by extracellular signals. Understanding how nuclear genes regulate mitochondrial functions is important for studying animal reproduction and human fertility. As more and more genes regulating mitochondrial functions in oocytes are being revealed, new approaches for improving female fertility in both human and animals through mitochondria can be developed.

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