Open Access

ARTICLE

The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis

by MEHMET TASPINAR, ALIHAN BOZOGLAN, ABDULLAH SECKIN ERTUGRUL, LEVENT ELMAS

1 Faculty of Medicine, Aksaray University, Aksaray, Turkey
2 Faculty of Medicine, Yuzuncu Yil University, Van, Turkey
3 Department of Periodontology, Faculty of Dentistry, Fırat University, Elazığ, Turkey
4 Department of Periodontology, Faculty of Dentistry, Yuzuncu Yil University, Van, Turkey
5 Department of Periodontology, Faculty of Dentistry, İzmir Katip Çelebi University, İzmir, Turkey 6 Faculty of Medicine, Pamukkale University, Denizli, Turkey

* Address correspondence to: Mehmet Taspinar,

(This article belongs to the Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)

BIOCELL 2020, 44(3), 337-344. https://doi.org/10.32604/biocell.2020.011470

Received 10 May 2020; Accepted 10 June 2020; Issue published 22 September 2020

Abstract

This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival crevicular fluid were measured. In both groups, following clinical periodontal treatment, a statistically significant decrease in white blood cells (WBC), low-density lipoproteins (LDL), fibrinogen, creatinine, and platelets (PLT), a statistically significant increase in high-density lipoproteins (HDL) in blood samples, statistically meaningful decrease in HBD-2, HBD-3, and calprotectin in the gingival crevicular fluid were achieved. Blood values and HBD-2, HBD-3, calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group. A positive correlation was observed between decreases in HBD-2, HBD-3, calprotectin, and clinical periodontal indices. Regression in systemic inflammation was observed after clinical periodontal treatment. It is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.

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