Open Access
REVIEW
The antitumor effects of Newcastle disease virus on glioma
Ji SHI; Peixin SUN, Ye ZHANG, Bing YAO, Haozhe PIAO
Department of Neurosurgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, China
* Address correspondence to: Haozhe Piao,
BIOCELL 2019, 43(3), 119-128. https://doi.org/10.32604/biocell.2019.07577
Abstract
Glioma is the most common primary malignant brain tumor with a poor survival rate. In recent years, no
significant progress has been made in the treatment of gliomas in contrast to the development of improved diagnosis
via molecular typing. Newcastle disease virus (NDV), a negative-stranded RNA virus that exhibits oncolytic activity,
has been investigated for its capacity to elicit antitumor activity in many types of cancers, including glioma. Therefore,
application of oncolytic viruses, such as NDV, as a new treatment strategy to specifically target aberrant signaling in
glioblastomas has brought new hope. For many years, NDV has been investigated for its
in vivo and
in vitro efficacy in
the treatment of various tumor cells. Based on its safety in humans, specificity for tumor cells, and immunostimulatory
properties, NDV represents a promising antitumor agent. In this review, we summarize the background of NDV and
the antitumor mechanisms of NDV-mediated oncolysis, discuss the potential value and role of NDV in gliomas, and
describe new advances and perspectives for future research.
Keywords
Cite This Article
APA Style
SUN, J.S.P., ZHANG, Y., YAO, B., PIAO, H. (2019). The antitumor effects of newcastle disease virus on glioma. BIOCELL, 43(3), 119-128. https://doi.org/10.32604/biocell.2019.07577
Vancouver Style
SUN JSP, ZHANG Y, YAO B, PIAO H. The antitumor effects of newcastle disease virus on glioma. BIOCELL . 2019;43(3):119-128 https://doi.org/10.32604/biocell.2019.07577
IEEE Style
J.S.P. SUN, Y. ZHANG, B. YAO, and H. PIAO "The antitumor effects of Newcastle disease virus on glioma," BIOCELL , vol. 43, no. 3, pp. 119-128. 2019. https://doi.org/10.32604/biocell.2019.07577