Open Access
ARTICLE
Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy
Entsar A. SAAD1, Reda S. EL-DEMERDASH2, Eman M. ABD EI-FATTAH1
1
Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt
2
Urology & Nephrology Center, Faculty of Medicine, Mansoura University, Egypt
* Address correspondence to: Entsar A. SAAD,
BIOCELL 2019, 43(2), 73-80. https://doi.org/10.32604/biocell.2019.07020
Abstract
Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use. We aimed to
evaluate the effect of mesenchymal stem cells (MSCs) injection or of captopril to counteract the cisplatin-induction
of nephropathy. MSCs isolation, preparation and tracking, transforming growth factor-β (TGF-β) and interleukin-10
(IL-10) expressions, kidney function tests, oxidative stress state, and histological examinations were done. Cisplatininduced nephropathy was indicated biochemically and confirmed histopathologically. MSCs treatment showed normal
kidney architecture, and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney
function tests. Rats treated with cisplatin + captopril showed noticeable kidney histopathological changes. Superior
positive impact of MSCs in amelioration of cisplatin-induced nephropathy via their ability to motivate functional and
structural renal repair is evidenced.
Keywords
Cite This Article
SAAD, E. A., EL-DEMERDASH, R. S., M., E. (2019). Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy.
BIOCELL, 43(2), 73–80. https://doi.org/10.32604/biocell.2019.07020