Open Access
REVIEW
Jesus Sebastian DISTEL1, Walter BERON1, Rodolfo Matias ORTIZ FLORES1,2
BIOCELL, Vol.43, No.1, pp. 1-6, 2019, DOI:10.32604/biocell.2019.07021
Abstract Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q fever. In this brief review, we describe how recently described mechanisms help our understanding of C. burnetii invasion and its survival in the host cell by the formation of a replicative niche: the Coxiella-containing vacuole. We describe the actin-associated proteins involved in the internalization of C. burnetii, and we discuss the contribution of diverse degradation pathways of the cell during the formation and stabilization of the Coxiella-containing vacuole. More >
Open Access
ARTICLE
Wen LI, Junli YANG, Dong ZHOU, Jinghui ZHANG, Qingcui ZHUO
BIOCELL, Vol.43, No.1, pp. 7-12, 2019, DOI:10.32604/biocell.2019.04763
Abstract The efficacy and safety of ganglioside in the treatment of neonates who suffer from hypoxic–ischemic
encephalopathy (HIE) needs to be fully evaluated. We searched the following databases: PubMed, ScienceDirect,
LISTA, CNKI, Chinese biomedical literature database and Wanfang digital journals of full-text database to determine
the inclusion and exclusion criteria of papers and a total of 12 papers were included after quality evaluation. Then we
conducted the meta-analysis with RevMan5.0 software. The results showed that compared with the control group, the
abnormal rate declined in the ganglioside-treated group (relative risk (RR)=0.27, 95% confidence interval (CI)= 0.05–
1.96). NBNA records of the… More >
Open Access
ARTICLE
Ana Laura CIMADOR1,#, Emeli Luciana GALANTE1,#, Lucila Ibel MUÑOZ1,#, Patricia Silvia ROMANO2,3, Antonella Denisse LOSINNO1,2, María Cristina VANRELL1,2,3
BIOCELL, Vol.43, No.1, pp. 13-20, 2019, DOI:10.32604/biocell.2019.07018
Abstract Trypanosoma rangeli and T. cruzi are both parasitic unicellular species that infect humans. Unlike T. cruzi,
the causative agent of Chagas disease, T. rangeli is an infective and non-pathogenic parasite for humans, but pathogenic
for vectors from the Rhodnius genus. Because both species can coexist in different hosts and overlap their infective
cycles but very little is known about the infection of T. rangeli in mammalian cells, we decided to characterize both the
development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on
it. We found that T. rangeli exhibits a cycle… More >
Open Access
ARTICLE
Nesrine EBRAHIM1, Eman EHSAN2, Eman Abd EL GHANY2, Dina SABRY3, Ashraf SHAMAA4
BIOCELL, Vol.43, No.1, pp. 21-28, 2019, DOI:10.32604/biocell.2019.06111
Abstract The neonatal hypoxic–ischemic encephalopathy (HIE) is an important cause of neurological morbidity and
mortality in neonates. Cell therapy is considered a promising method for treating severe neurological disorders such as
this one. Stem cells have the capacity for self-renewal and differentiation into certain cell lineages. The present study was
aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells (BMSCs) administration
for the attenuation of experimentally induced HIE in neonatal rats. Sixty neonatal rats were divided randomly into
four groups. Group 1: control group. Group 2: rats were exposed to bilateral ligation of cephalic arteries. Group… More >
Open Access
ARTICLE
Odin RAMÍREZ-FERNÁNDEZ1,2,3,*, Ludovika CACOPARDO1, Benjamín LEON-MANCILLA2, Joana COSTA1
BIOCELL, Vol.43, No.1, pp. 29-36, 2019, DOI:10.32604/biocell.2019.04790
Abstract We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic
nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed
presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment
of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine
model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor
can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy with
the previously described in… More >
Open Access
ARTICLE
Manoochehr MESSRIPOUR1, Azadeh MESRIPOUR2
BIOCELL, Vol.43, No.1, pp. 37-40, 2019, DOI:10.32604/biocell.2019.05865
Abstract DNA damage and the enzyme poly (ADP-ribose) polymerase (PARP) associated with the pathogenesis
of numerous age-related neurodegenerative disorders. Astrocytes play crucial roles in both support metabolic
functions and cell viability of the brain. PARP regulates DNA damage and repair in the brain cells. In this study PARP
activity and DNA strand break were investigated in the astrocytes isolated from young and aged rat brain. Three and
30-month-old rats were killed by decapitation and brains were removed onto an ice cooled glass plate. Astrocytes were
isolated by sucrose density gradient centrifugation and glutamine synthetase (GS) served as a marker of the… More >
Login
Register
Submit a Paper
Propose a Special lssue