BIOCELL-Vol. 42, No. 2, 2018

Open Access

ARTICLE

Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship
Maximiliano GIRAUD-BILLOUD^1,2,*, Claudio M. FADER^1,3, Rocío AGÜERO², Fernando EZQUER⁴, Marcelo EZQUER⁴
BIOCELL, Vol.42, No.2, pp. 35-40, 2018, DOI:10.32604/biocell.2018.07010
Abstract Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated. In the present study, we evaluate the role of autophagy at early stages of DN, induced in type 2 diabetes mellitus (T2DM) mouse, and its association with proximal tubule membrane endocytic receptors, megalin and cubilin. In T2DM animals we observed a tubule-interstitial injury with significantly increased levels of urinary GGT and ALP, but an absence of tubulointerstitial fibrosis. Kidney proximal tubule cells of T2DM animals showed autophagic… More >

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REVIEW

Microglia-precursor cell interactions in health and in pathology
Estela M. MUÑOZ
BIOCELL, Vol.42, No.2, pp. 41-46, 2018, DOI:10.32604/biocell.2018.07011
Abstract Until recently, microglia were mainly known as the resident phagocytes of the brain, i.e. the ‘immunological warriors’ of the brain. However, extensive knowledge is being accumulated about the functions of microglia beyond immunity. Nowadays, it is well accepted that microglial cells are highly dynamic and responsive, and that they intervene in a dual manner in many developmental processes that shape the central nervous system, including neurogenesis, gliogenesis, spatial patterning, synaptic formation and elimination, and neural circuit establishment and maturation. The differentiation and the pool of precursor cells were also shown to be under microglia More >

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ARTICLE

Characterization of multidrug-resistant Klebsiella pneumoniae isolated from the Chinese cobra Naja atra in a Beijing suburb
Haifeng WANG^{1, 2, 3}, Hongxuan HE²
BIOCELL, Vol.42, No.2, pp. 47-54, 2018, DOI:10.32604/biocell.2018.07006
Abstract The emergence and spread of antibiotic resistance genes among Bacteria are a serious threat to global health. Their occurrence in animals which are in contact with humans is also important. The Chinese cobra (Naja atra, Elapidae), though a highly venomous species, is appreciated as food and as a source of materials used in traditional Chinese medicine. We are here reporting the isolation of multidrug-resistant Klebsiella pneumoniae (Enterobacteriaceae) from the lung of Naja atra, obtained from a snake farm in a Beijing suburb. Our study analyzed, using gene sequencing, the occurrence of antibiotic resistance genes (ARGs) in… More >

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ARTICLE

Associations between CD133, CK19 and G2/M in cirrhotic HCV (genotype-4) patients with or without accompanying tumor
Hoda M. EL-EMSHATY¹, Entsar A. SAAD², Mona S. GOUIDA³, Zahraa R. ELSHAHAWY^1,2
BIOCELL, Vol.42, No.2, pp. 55-60, 2018, DOI:10.32604/biocell.2018.07009
Abstract Hepatitis C virus (HCV)-cirrhotic patients have the highest threat of developing hepatocellular carcinoma (HCC) and may be at risk of extra hepatic cancer. The present study was designed to investigate CD133 and CK19 in HCV (genotype-4)-cirrhotic patients with/without HCC or extra hepatic cancer, to assess the degree of their correlation with cell cycle abnormalities and finally to assess the role of their combination as diagnostic tool for discrimination of cirrhotic patients with HCC from those with extra hepatic cancer. The study included 77 HCV-cirrhotic patients and 20 healthy non-disease control group. Patients were categorized… More >

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ARTICLE

Effects of precipitation changes on the dynamics of sparse elm woodland in Northeastern China
Yi TANG^1,*, Carlos Alberto BUSSO²
BIOCELL, Vol.42, No.2, pp. 61-66, 2018, DOI:10.32604/biocell.2018.07015
Abstract Elm (Ulmus pumila L.) is the dominant tree species in the sparse elm woodland, the original vegetation in the Horqin Sandy Land. The effects of changes in precipitation on U. pumila trees have not been fully studied. We determined a dynamic model by considering the five stages in the U. pumila life cycle, i.e. seed, seedling, and juvenile, mature and over-mature tree stages. The effects of changes in precipitation on population density and age structure were then evaluated. Population density, after averaging all study developmental morphology stages, ranged from 16.67 individuals/m2 to 25.01 individuals/m2 under More >

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