Open Access

ARTICLE

Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine

Anna PAŃCZYSZYN^{1 *}, Anna KROP-WATOREK^1,2, Maciej WIECZOREK¹

1 University of Opole, Department of Biotechnology and Molecular Biology, Opole, Poland
2 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

* Address correspondence to: Anna Pańczyszyn,

BIOCELL 2015, 39(2-3), 1-4. https://doi.org/10.32604/biocell.2015.39.001

Abstract

Carcinoembryonic antigen (CEA) is a surface glycoprotein expressed in human epithelial cells and is released from their surface, especially during colorectal cancer. Frequently, colorectal cancer is accompanied by inflammation, where tumor-infiltrating neutrophils play an important role. CEA was also found to be a strong chemotactic agent for neutrophils. The purpose of this study was to find out if CEA can enhance neutrophil priming and activation. Primed neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine (formyl-MLP) and the resulting oxidative burst was measured luminometrically. Unexpectedly, in vitro priming of neutrophils by CEA, alone or preceded by LPS, inhibited subsequent activation of these cells by formyl-MLP. CEA may have anti-inflammatory properties in vivo.

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Keywords

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