TY - EJOU AU - SUBRAMANI, Tamilselvan AU - RAO, Suresh AU - SENTHILKUMAR, Kamatchiammal AU - PERIASAMY, Soundararajan AU - ALITHEEN, Noorjahan Banu TI - Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts T2 - BIOCELL PY - 2013 VL - 37 IS - 3 SN - 1667-5746 AB - The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibroblast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells. KW - Angiotensin KW - c-Jun KW - c-Fos KW - transcription factor KW - cyclosporine KW - gingival overgrowth DO - 10.32604/biocell.2013.37.071