Open Access

ARTICLE

Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts

by Tamilselvan SUBRAMANI, Suresh RAO, Kamatchiammal SENTHILKUMAR, Soundararajan PERIASAMY, Noorjahan Banu ALITHEEN

1Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
2 Department of Periodontics, Faculty of Dental Science, Sri Ramachandra University, Chennai, India.
3 Virology Division, National Environmental Engineering Research Institute, Chennai, India.
4 Department of Nephrology, Faculty of Medicine, Sri Ramachandra University, Chennai, India.

*Corresponding author:

BIOCELL 2013, 37(3), 71-76. https://doi.org/10.32604/biocell.2013.37.071

Abstract

The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibroblast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells.

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