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Meta-analysis of the cell cycle related C12orf48

LOKMAN VARISLI
Harran University, Art and Science Faculty, Department of Biology, Osmanbey Campus, Sanliurfa, Turkey
* Address correspondence to: Lokman Varisli. Department of Biology, Science Faculty, Harran University, Osmanbey Campus, Sanliurfa, Turkey. E-mail:

BIOCELL 2013, 37(1), 11-16. https://doi.org/10.32604/biocell.2013.37.011

Abstract

The cell cycle is a conserved process from yeast to mammals and focuses on mechanisms that regulate the timing and frequency of DNA replication and cell division. The temporal and spatial expression of the genes is tightly regulated to ensure accurate replication and transmission of DNA to daughter cells during the cycle. Although the genes involved in interphase are well studied, most of the genes which are involved in mitotic events still remain unidentified. Since, the discovery of mitosis related genes is still incomplete, we performed a co-expression and gene ontology analysis for revealing novel mitosis regulated genes. In this study, we showed that C12orf48 is co-expressed with well-known mitotic genes. Moreover, it is also co-expressed with the genes that have roles in interphase such as DNA replication. Furthermore, our results showed that C12orf48 is also differentially expressed in various cancers. Therefore, the results presented in this study suggest that C12orf48 may be an important molecule for both interphase and mitosis. Since, the molecules involved in these mechanisms are crucial for proliferation as well as in carcinogenesis, C12orf48 should be considered as a novel cell cycle and carcinogenesis related gene.

Keywords

C12orf48, cell cycle, co-expression, gene ontology, oncomine

Cite This Article

VARISLI, L. (2013). Meta-analysis of the cell cycle related C12orf48. BIOCELL, 37(1), 11–16.

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This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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