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ARTICLE

Brief Note: CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity

LIPING ZHOU*, XIAOLIN GUO, JING BA, LIANSHUANG ZHA

Department of Laboratory Medicine, First Affiliated Hospital, China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001, China.

*Address correspondence to: Liping Zhou. E-mail:

BIOCELL 2010, 34(2), 91-94. https://doi.org/10.32604/biocell.2010.34.091

Abstract

CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.

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