Open Access

ARTICLE

Brief Note : Salicylic acid permeation: A comparative study with different vehicles and membranes

MÓNICA S. OLIVELLA, NORA B. DEBATTISTA, NORA B. PAPPANO

Proyecto 9101- Área de Química Física, Dpto. de Química. Universidad Nacional de San Luis. Chacabuco y Pedernera. (5700) San Luis, Argentina.
Address correspondence to: Dra. Mónica S. Olivella. Área de Química Física, Dpto. de Química. Universidad Nacional de San Luis. Chacabuco y Pedernera. (5700) San Luis, ARGENTINA. E-mail: olivella@unsl.edu.ar / npappano@unsl.edu.ar

BIOCELL 2006, 30(2), 321-324. https://doi.org/10.32604/biocell.2006.30.321

Abstract

Considering the skin´s function, different dermal pharmaceutical forms can be developed according to the type of therapeutic activity, active principle and excipients involved in the formulation, such as “transdermal preparations”. In the present study, the permeation parameters of the non-steroidal antiinflammatory drug, salicylic acid (SA) through synthetic membrane, polyvinyliden difluoride, and a biological membrane, egg shell membrane, with different vehicles, propylene glycol, isopropyl alcohol and carbopol gel, were determined. The reported physicochemical parameters of SA from CG were significantly higher than those obtained using PG and IP. This is attributed to the lipophilic nature of the vehicle that facilitates the release and penetration of the active principle, thus acting sinergically. The permeation profiles of SA allow us to state that permeation kinetics is of first order, so that the flux values obtained are in direct proportion to the specific rates of drug release.

---

Keywords

---