Guest Editors
Professor Dr. Jafar Rezaie, Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Iran. Rezaie.j@umsu.ac.ir
Summary
Extracellular vesicles (EVs) are phospholipid bilayer vesicles released from tumor and non-tumor cells for intercellular communication. EVs contain different types of proteins, nucleic acids, and lipids that contribute to affect target cell function and fate. Three main subclasses of EVs including exosomes, microvesicles, and apoptotic bodies have been categorized, which represent pivotal roles in cellular physiology. Exosomes, 30-150 nm EVs, have dramatically fascinated the attention of researchers owing to their pivotal roles in carcinogenesis and cancer treatment. Exosomes biogenesis may show a crosstalk with other signaling pathways such as autophagy, apoptosis, and P53/TSPA6 to preserve cellular hemostasis.
This Special Issue is dedicated to the roles of EVs in cancer progress and treatment, with specific highlighting on the role of exosomes as cell-to-cell communication mediators in cancer management.
Areas of interest include, but are not limited to:
• Exosomes signaling pathway in tumor cells.
• Tumor angiogenesis and exosomes/microvesicles.
• Tumor immunology and exosomes/microvesicles.
• Tumor resistance to therapies and exosomes.
• Exosomes as drug-delivery particles.
• Exosomes therapy for cancer.
• Exosomes and biomarkers for cancer.
• Crosstalk between exosomes, autophagy and apoptosis signalings
Keywords
Extracellular vesicles; Exosomes; Tumor environment; Drug-delivery; Biomarker; Exosomes-autophagy crosstalk
Published Papers
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Open Access
REVIEW
Therapeutic application of mesenchymal stem cells-derived extracellular vesicles in colorectal cancer
MOHADESEH NEMATI, YOUSEF RASMI, JAFAR REZAIE
BIOCELL, Vol.47, No.3, pp. 455-464, 2023, DOI:10.32604/biocell.2023.025603
（This article belongs to this Special Issue:
Extracellular Vesicles and Cancer)
Abstract Colorectal cancer (CRC) is the third most common cancer and the leading cause of cancer death globally. Resistance to therapy is a challenge for CRC treatment. Mesenchymal stem cells (MSCs) have become one of the furthermost effective approaches for tumor treatment due to their specific feature; however, their therapeutic function is controversial. Recently, extracellular vesicles (EVs) derived from MSCs (MSCs-EVs) have attracted extensive research attention due to their promising role in CRC treatment. EVs are cell-derived vesicles that transfer different biomolecules between cells, contributing to intracellular communication. MSCs-EVs can suppress CRC by delivering therapeutic agents to tumor cells. Several studies…
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Open Access
ARTICLE
Exosomes: Key tools for cancer liquid biopsy
ISABELLA PANFOLI, MAURIZIO BRUSCHI, GIOVANNI CANDIANO
BIOCELL, Vol.46, No.10, pp. 2167-2176, 2022, DOI:10.32604/biocell.2022.020154
（This article belongs to this Special Issue:
Extracellular Vesicles and Cancer)
Abstract Precision medicine is based on the identification of biomarkers of tumor development and progression. Liquid
biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors, as it can be
noninvasively performed prior or during treatment. Liquid biopsy mostly utilizes circulating tumor cells, or free DNA,
but also exosomes. The latter are nanovesicles secreted by most cell types, found in any body fluid that deliver
proteins, nucleic acids and lipids to nearby and distant cells with a unique homing ability. Exosomes function in
signalling between the tumor microenvironment and the rest of the body, promoting…
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