Guest Editors
Dr. Rishi Man Chugh
Email:rchugh@kumc.edu
Affiliation: Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Homepage:
Research Interests:radiation oncology, radiation therapy, GI-ARS, cell therapy, progenitor stem cell therapy
Dr. Rajnikant Sharma
Email:rajnikan@usc.edu
Affiliation: Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA
Research Interests:antimicrobial resistance, microbial infections
Summary
Stem cells, renowned for their remarkable abilities to self-renew and differentiate into various cell types, have become a cornerstone of biological and medical research. These unique cells play crucial roles in tissue development, maintenance, and repair, and have significant implications for understanding and treating a variety of diseases. This special issue aims to compile the latest research advancements globally, focusing on the cellular and molecular mechanisms of stem cells in both health and disease. The issue will cover, but not be limited to, the following key areas:
1. Fundamental Mechanisms of Stem Cells:
- Investigating the signaling pathways and gene regulatory networks that maintain stem cell pluripotency and self-renewal.
- The roles of Wnt, Notch, Hedgehog, and other pathways in stem cell fate determination.
2. Role of Stem Cells in Health:
- The functions of various stem cell types in normal physiological conditions, such as hematopoietic, intestinal epithelial, and neural stem cells.
- How stem cells contribute to tissue homeostasis and repair through continuous cell renewal.
- The influence of the microenvironment in regulating stem cell behaviour and maintaining tissue integrity.
- How wnt/b-catenin signalling helps in maintenance and repair of stem cells after an injury.
- How stem cells therapy helps control the body's infection after a wound/burn injury.
3. Therapeutic Applications and Challenges:
- Progress and challenges in stem cell-based therapies, including safety, heterogeneity, and immune rejection issues.
- Innovative strategies to enhance the efficacy and safety of stem cell treatments.
- Future research directions and potential clinical applications of stem cells in regenerative medicine and precision medicine.
This special issue seeks to highlight the importance of stem cells in health and disease through multidisciplinary research findings, fostering collaboration and communication in the field. We welcome original research, reviews, and case studies from researchers worldwide to discuss the potential and challenges of stem cells in both basic research and clinical applications.
Keywords
stem cell pluripotency, cellular differentiation, signal transduction pathways, tissue homeostasis, regenerative medicine, stem cell therapy, microbial infection
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