Guest Editors
Assoc. Prof. Dr. Kok-Yong Chin
Email: chinky@ukm.edu.my
Affiliation: Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
Homepage:
Research Interests: osteoporosis, osteoarthritis, sarcopenia, epidemiology, natural products
Dr. Kok-Lun Pang
Email: koklun.pang@monash.edu
Affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500 Petaling Jaya, Malaysia
Homepage:
Research Interests: cancer biology, cell death, pharmacognosy, toxicology
Summary
Skeletal health is a critical aspect of overall well-being, particularly in the context of aging, where it undergoes significant changes that can lead to conditions like osteoporosis, osteoarthritis, and fractures. This special issue aims to explore the molecular mechanisms underlying skeletal health and aging, as well as potential therapeutic strategies to mitigate age-related bone loss and improve bone regeneration. By bringing together cutting-edge research from global experts, this issue seeks to deepen our understanding of the complex biological processes involved in bone metabolism and aging.
Key areas of focus include, but are not limited to:
1. Molecular Mechanisms in Bone Metabolism and Aging:
-Investigating how aging affects bone formation and resorption at the cellular and molecular levels.
-Exploring the role of key signaling pathways, such as Wnt/β-catenin and RANK/RANKL, in age-related bone remodeling.
-Analyzing how the bone marrow microenvironment changes with age, affecting bone health and regeneration.
2. Bone Loss and Osteoporosis in Aging:
-Understanding the molecular basis of osteoporosis, focusing on the role of hormones, such as estrogen and testosterone, and their decline with aging.
-Investigating genetic, epigenetic, and environmental factors that contribute to osteoporosis risk in aging populations.
-Exploring biomarkers for early detection and progression of osteoporosis and related fractures.
3. Therapeutic Strategies for Bone Health in Aging:
-Examining current and emerging pharmacological treatments for bone diseases in the elderly, including bisphosphonates, denosumab, and anabolic therapies.
-Investigating the potential of exercise, nutrition, and lifestyle interventions in improving bone density and reducing fractures in aging populations.
-Exploring novel drug delivery systems and regenerative medicine approaches, such as stem cell therapy and gene editing, for bone tissue repair and regeneration.
4. The Role of Vitamin E and Other Nutrients in Skeletal Health:
-Unraveling the molecular mechanisms by which Vitamin E and other antioxidants influence bone metabolism and protect against oxidative stress in aging bones.
-Examining the interplay between vitamin D, calcium, and other micronutrients in maintaining skeletal health and preventing bone loss.
-Studying dietary interventions and their impact on aging bones and musculoskeletal health.
5. Age-Related Osteoarthritis and Joint Health:
-Investigating the molecular and cellular mechanisms driving osteoarthritis progression in aging joints.
-Exploring therapeutic approaches to alleviate osteoarthritis symptoms and slow its progression, including novel drug therapies and regenerative medicine.
We invite original research articles, comprehensive reviews, and perspectives that delve into the molecular mechanisms of skeletal health and aging, and how these insights can be translated into effective therapeutic strategies. By showcasing the latest advancements in bone biology and therapeutic innovations, this special issue aims to provide new directions for enhancing bone health in aging populations and developing targeted treatments for age-related bone diseases.
Keywords
skeletal health, aging, bone metabolism, osteoporosis, therapeutic strategies, bone regeneration, vitamin E, aging joints, molecular mechanisms, osteoarthritis, stem cell therapy, nutrition
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