Guest Editors
Dr. Zhigang Xue, Tongji University School of Medicine, Shanghai, China. xuezg@tongji.edu.cn
Dr. Jinfeng Xue, Tongji University School of Medicine, Shanghai, China. xuejinfeng@tongji.edu.cn
Summary
Reproductive health is a state of the individual reproductive system, reproductive process and reproductive ability in each stage of life. Disease, pathological changes, gene expression, gene mutation, environment, stress and others can affect reproductive health, and even lead to infertility or sterility, abnormal embryonic development and birth defects. Study on these influencing factors can help to improve people's fertility, reproductive system function as well as the health of offspring, and further to explore the initiation and differentiation of life.
This current special issue focuses on a wide range of topics related to reproductive healthy and embryonic development. We invite researchers in this field to submit your original article, reports and reviews in this special issue. Potential topics include but are not limited to the followings:
• Pathogenesis of reproductive and related disease
• Influencing factors of reproductive health and ability
• Assisted reproduction
• Gametogenesis
• Cellular and molecular profiling of early embryonic development
• Fetal developmental abnormalities and prenatal diagnosis
Keywords
Reproductive health, Embryonic development, Pathogenesis, Assisted reproduction, Prenatal diagnosis
Published Papers
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Open Access
ARTICLE
Advanced glycation end-products change placental barrier function and tight junction in rats with gestational diabetes mellitus via the receptor for advanced glycation end products/nuclear factor-κB pathway
YUEHUA SHI, QIUYING YAN, QIN LI, WEI QIAN, DONGYAN QIAO, DONGDONG SUN, HONG YU
BIOCELL, Vol.47, No.1, pp. 165-173, 2023, DOI:10.32604/biocell.2022.023043
（This article belongs to this Special Issue:
Reproductive Health and Embryonic Development)
Abstract The placenta plays an important role in nutrient transport to maintain the growth and development of the
embryo. Gestational diabetes mellitus (GDM), the most common complication during pregnancy, highly affects
placental function in late gestation. Advanced glycation end-products (AGEs), a complex and heterogeneous group of
compounds engaged by the receptor for AGEs (RAGE), are closely associated with diabetes-related complications. In
this study, AGEs induced a decrease in the expression of tight junction (TJ) proteins in BeWo cells and increased the
paracellular permeability of trophoblast cells by regulating RAGE/NF-κB. Sprague-Dawley (SD) rats injected with
100 mg/kg AGEs-rat serum albumin (RSA) via…
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Open Access
ARTICLE
Induction of adaptive response in utero by ionizing radiation: A radiation quality dependent phenomenon
BING WANG, KAORU TANAKA, KOUICHI MARUYAMA, YASUHARA NINOMIYA, TAKANORI KATSUBE, MITSURU NENOI
BIOCELL, Vol.46, No.10, pp. 2315-2325, 2022, DOI:10.32604/biocell.2022.021161
（This article belongs to this Special Issue:
Reproductive Health and Embryonic Development)
Abstract Investigation on possible induction of adaptive response (AR) by high-liner energy transfer (LET) particle
radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed
in
utero. This study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions
against low-LET X-ray radiation-induced detrimental effects on fetal mice. Total body irradiation of pregnant
C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation
on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray radiation. The monoenergetic…
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Open Access
REVIEW
Current and future therapies for abnormal early embryogenesis with assisted reproductive technology
XIAOXIA WANG, ZHONGYUAN YAO, DI LIU, CHUNHONG YU, HUI LI
BIOCELL, Vol.46, No.8, pp. 1803-1806, 2022, DOI:10.32604/biocell.2022.019731
（This article belongs to this Special Issue:
Reproductive Health and Embryonic Development)
Abstract Each stage of embryonic development, including normal gamete maturation, fertilization, zygotic genome activation, and cleavage, is crucial for human reproduction. Early embryo arrest is a common phenomenon. It is estimated that about 40%–70% of human embryos are arrested at early developmental stages. However, the exact mechanism remains largely uncertain. Embryos can be investigated
in vitro by way of the development of
in vitro fertilization/intracytoplasmic sperm injection. In addition to iatrogenic factors related to abnormal oocyte/embryo development, multiple gene mutations have been found to be involved in such phenotypes. Based on the knowledge of known etiological factors, several therapies are proposed…
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Open Access
ARTICLE
Should we continue breastfeeding after SARS-CoV-2 infection or mRNA vaccination?
FEI CHEN, CHUN LUAN, ZICHUN WEI, DECHEN CAI, ZHIWEN CUI, YUYANG LI, HAO WU, XIAOXIA ZHANG, XIAOLI WU
BIOCELL, Vol.46, No.6, pp. 1425-1433, 2022, DOI:10.32604/biocell.2022.019868
（This article belongs to this Special Issue:
Reproductive Health and Embryonic Development)
Abstract The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a potential threat to infant health. The World Health Organization recommended that the benefits of breastfeeding far outweigh the potential risk of transmission, but there is no denying that the current evidence is insufficient. Moreover, although the COVID-19 mRNA vaccine has played an effective role in protection against infection, individuals have increasing concerns about the safety of breastfeeding after vaccination, and which have caused some breastfeeding women to postpone vaccination or stop breastfeeding early. Thus, in this review, we provide an in-depth…
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Open Access
VIEWPOINT
Cannabis and male reproduction: Impact on offspring via sperm epigenome
PAOLA GRIMALDI
BIOCELL, Vol.46, No.2, pp. 301-304, 2022, DOI:10.32604/biocell.2022.017588
（This article belongs to this Special Issue:
Reproductive Health and Embryonic Development)
Abstract Cannabis is the most widely used drug in the Western societies particularly among adolescent and young adults. Epidemiological studies demonstrate that men use cannabis more frequently than women with higher risk in developing cannabis-related disorders. Although the direct adverse effects of cannabis on male reproductive functions have been studied both in humans and animal models, the possible long-term risks for the health of the users and their offspring are still an area of active research.
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Open Access
ARTICLE
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