Guest Editors
Dr. Fucheng Liang
Email: fucheng.liang@msutexas.edu
Affiliation: Department of Chemistry, Midwestern State University, Wichita Falls, TX, USA.
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Research Interests: protein targeting and transport across cell membranes, protein folding and misfolding or amyloid formation, membrane protein biogenesis, treatment of Alzheimer's and Parkinson’s disease, protein structural and functional studies by NMR and fluorescence spectroscopy
Summary
Protein misfolding and aggregation are central to the pathology of several neurodegenerative diseases, including Alzheimer's and Parkinson's disease. This special issue aims to delve into the cellular and molecular underpinnings of these protein misfolding diseases, with a focus on understanding the intricate processes that drive disease progression and exploring innovative therapeutic approaches.
By gathering leading research from global experts, this issue seeks to illuminate the fundamental mechanisms and identify new therapeutic targets for combating these debilitating disorders. Key areas of focus include, but are not limited to:
1. Protein Targeting and Membrane Transport:
· Investigating the cellular pathways that govern protein targeting and transport across membranes.
· Understanding how dysfunctions in these pathways contribute to protein aggregation and neurodegeneration.
2. Protein Folding, Misfolding, and Amyloid Formation:
· Exploring the molecular mechanisms of protein folding and misfolding.
· Examining how amyloid formation contributes to the development and progression of neurodegenerative diseases.
3. Membrane Protein Biogenesis:
· Studying the biogenesis of membrane proteins and its impact on cellular health.
· Analyzing how disruptions in membrane protein biogenesis are linked to disease states.
4. Therapeutic Strategies for Alzheimer's and Parkinson's Disease:
· Evaluating novel therapeutic approaches targeting protein aggregation and misfolding.
· Highlighting advancements in drug development and molecular interventions aimed at treating neurodegenerative diseases.
5. Technological Advances in Protein Biochemistry:
· Developing new tools and techniques for studying protein folding, misfolding, and aggregation in cellular contexts.
· Innovations in therapeutic delivery systems targeting protein misfolding diseases.
Through this special issue, we aim to foster a deeper understanding of the cellular mechanisms underlying protein misfolding diseases and promote the development of effective therapeutic strategies. We welcome original research articles, comprehensive reviews, and perspectives that explore the multifaceted roles of protein misfolding in disease pathogenesis and therapy. By showcasing the latest discoveries and challenges in the field, this issue aspires to pave the way for novel treatments and improved outcomes for patients suffering from neurodegenerative diseases.
Keywords
amyloid beta, protein misfolding disease, protein aggregation, Alzheimer's disease, Parkinson's disease, protein targeting and membrane transport, membrane protein biogenesis, protein biochemistry
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