Guest Editors
Dr. Ananth Kumar Kammala
Email: ankammal@utmb.edu
Affiliation: Division of Basic and Translational Research, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, TX, USA
Homepage:
Research Interests: pharmacokinetics, exosomes, preterm birth, pregnancy, transporter proteins
Dr. Ourlad Alzeus G. Tantengco
Email: ogtantengco@up.edu.ph
Affiliation: Department of Physiology, College of Medicine, University of the Philippines Manila, Manila, Philippines
Research Interests: obstetrics and gynecology, gynecologic infection, gynecologic oncology, cervical remodeling, extracellular vesicles, organ-on-a-chip technology
Summary
Extracellular vesicles (EVs) are nanoscale lipid bilayer structures released by various cells, playing crucial roles in intercellular communication and modulating various physiological and pathological processes. In recent years, EVs have garnered significant attention for their potential implications in obstetrics and gynecology, particularly concerning pregnancy complications and gynecological malignancies.
This special issue aims to investigate the multifaceted roles of extracellular vesicles in obstetrics and gynecology, highlighting their applications as biomarkers for disease diagnosis and prognosis and their therapeutic potential. We invite submissions that offer novel insights into how EVs influence placental development, maternal-fetal communication, and the progression of gynecological diseases. Topics of interest include, but are not limited to:
1. Extracellular Vesicles in Pregnancy:
-Mechanisms of EV-mediated communication between maternal and fetal compartments.
-The role of EVs in placental development and function.
2. EVs in Gynecological Diseases:
-The impact of EVs on the pathogenesis of conditions such as endometriosis, polycystic ovary syndrome, and gynecological cancers.
-Use of EVs as biomarkers for early diagnosis and monitoring of disease progression.
3. Molecular Composition of EVs:
-Characterization of RNA, proteins, and lipids within EVs and their implications for cellular signaling in obstetric and gynecological contexts.
-Functional analysis of specific EV cargo (e.g., microRNAs) mediating cellular responses.
4. Therapeutic Applications of EVs:
-Exploration of EVs as vehicles for drug delivery and their potential in targeted therapy for gynecological cancers.
-Strategies for harnessing EVs to modulate immune responses during pregnancy and in tumor microenvironments.
5. Mechanisms of EV Biogenesis and Release:
-Insights into the cellular processes governing EV formation and secretion in placental and tumor cells.
-Factors influencing the heterogeneity of EV populations in different physiological and pathological states.
6. Clinical Implications of EV Research:
-The translational potential of EVs in clinical diagnostics and therapeutic interventions in obstetrics and gynecology.
-Ethical considerations and challenges in the clinical application of EV-based therapies.
We welcome original research articles, reviews, and perspectives that deepen our understanding of the roles of extracellular vesicles in obstetrics and gynecology. Manuscripts should provide mechanistic insights and robust experimental data to elucidate the complex interactions and processes involving EVs in these fields.
Keywords
obstetrics, gynecology, preterm birth, gynecologic infection, gynecologic malignancy, exosomes, microvesicles, bacterial extracellular vesicles, apoptotic bodies
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