Guest Editors
Dr. Jagpreet Nanda, National Institute of Health (NIH), USA. jagpreet.nanda@nih.gov
Dr. Shardul Kulkarni, Penn State University, USA. Smk6881@psu.edu
Dr. Abdul Khalique, National Institute of Health (NIH), USA. abdul.khalique@nih.gov
Summary
Approximately 80% of human genome is transcribed into noncoding RNAs (ncRNAs) including long noncoding RNAs (LncRNAs), small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), micro RNAs (miRNAs), small interfering RNAs (siRNAs), transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), and circular RNAs, that plays very crucial role in regulation of cellular function. The comparative genomics analysis of various organisms has strongly suggested that the genomic complexity of eukaryotes lies in the ncRNAs. The ncRNAs are shown to play roles in controlling the gene expression by simply base pairing with other nucleic acid targets and proteins, and can regulate transcription, RNA processing, mRNA translation and degradation. In addition to their regulatory functions on controlling coding gene expression, they can interact and regulate with each other by various molecular mechanisms generating complex network. Thus, their dysfunctions or expression variability may affect their biological roles which may cause various pathological phenotypes including neurodevelopmental disorders, metabolic diseases and cancer. Over the past few years, lot of focus has been put on the functional role of the ncRNAs in disease progression. However, the mechanistic details of ncRNAs mediated disease progression and gene expression control still remain to be investigated. Additionally, recent reports suggest that there is a connection between ncRNAs dysfunction and Covid19 disease progression, but more research is required to unravel to link between COVID-19 biology and ncRNAs.
This special issue will focus on the novel findings and recent research and development in ncRNAs with respect to their regulatory functions that could associate it to the human disease progression. We invite authors to submit wide range of manuscripts, including experimental research, methodologies, short commentary and review articles pertaining to the role of ncRNAs and disease progression.
Keywords
ncRNAs, Gene Expression Regulation, Human Diseases
Published Papers
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