Table of Content

Non-Coding RNAs in the Regulation of Human Cancers

Submission Deadline: 01 July 2023 Submit to Special Issue

Guest Editors

Prof. Lei Yang,
Department of Orthopedics, Nanjing Medical University, Nanjing, China

Prof. Athanasios E. Athanasiou,
Department of Medical Oncology, Metaxa Cancer Hospital, Botassi 51, 18537, Piraeus, Greece

Prof. Francesco Busardò,
University Politecnica delle Marche, Ancona, Italy


Non-Coding RNAs (ncRNAs) are RNA molecules transcribed from the genome that do not encode proteins, and can be divided into small noncoding RNAs (snRNAs, snoRNAs, miRNAs, and piRNAs) and long noncoding RNAs (>200 nucleotides). More and more evidence have demonstrated the important role of ncRNAs in the physiological and pathological processes of human cancers. Due to the wide variety of ncRNAs and their mechanisms of action, it is a difficult task to understand how changes in ncRNA expression promote the progression of cancer. In addition, changes in ncRNA expression levels are usually cancer-specific or even subtype-specific, which makes the wide application of research results challenging. Nevertheless, an in-depth understanding of the nuances of ncRNA regulation provides more opportunities for new therapeutic targets. The main aim of this special issue is to further understand the mechanism of ncRNAs and their influences on the signaling network of cancers in order to develop better prognosis and treatment strategies.


This special issue on the “Non-Coding RNAs in the Regulation of Human Cancers” welcomes interesting articles as well as reviews that focus on the emerging important role of non-coding RNAs in the diagnosis and treatment of kinds of cancers.


Areas of interest include, but are not limited to:

1) The molecular mechanism of miRNAs in the occurrence and development of human cancers;

2) The molecular mechanism of lncRNAs in the occurrence and development of human cancers;

3) The molecular mechanism of circRNAs in the occurrence and development of human cancers;

4) The molecular mechanism of snRNAs in the occurrence and development of human cancers;

5) The molecular mechanism of , snoRNAs in the occurrence and development of human cancers;

6) The molecular mechanism of , piRNAs in the occurrence and development of human cancers;

7) Biological functions of ncRNAs combined with exosomes in human cancers;

8) Bioinformatics of ncRNAs in human Cancers;

9) Systematic review and Meta-analysis of ncRNAs in human Cancers;

10) The role of ncRNAs in the therapeutic effects and prognosis of human Cancers.


Non-Coding RNAs, Diagnosis, Cancer, Biomarker, Therapeutics

Published Papers

  • Open Access


    Roles of miR-214 in bone physiology and disease

    BIOCELL, Vol.47, No.4, pp. 751-760, 2023, DOI:10.32604/biocell.2023.026911
    (This article belongs to this Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
    Abstract MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that regulate the expression of their target mRNAs post-transcriptionally. Since their discovery, thousands of highly conserved miRNAs have been identified and investigated for their role in human health and diseases. MiR-214 has been increasingly reported to have an association with the regulation of bone metabolism. Reports suggested that miR-214 controls the critical aspects of osteoblasts (bone-forming cells), including their differentiation, proliferation, viability, and migration. Studies have also reported the functional significance of miR-214 in bone diseases and suggested its candidature as a diagnostic and therapeutic target. Further, targeting miR-214 by other ncRNAs, such… More >

  • Open Access


    MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis

    BIOCELL, Vol.47, No.3, pp. 547-554, 2023, DOI:10.32604/biocell.2023.025048
    (This article belongs to this Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
    Abstract Background: The Warburg effect is considered as a hallmark of various types of cancers, while the regulatory mechanism is poorly understood. Our previous study demonstrated that miR-194-5p directly targets and regulates insulin-like growth factor1 receptor (IGF1R). In this study, we aimed to investigate the role of miR-194-5p in the regulation of the Warburg effect in ovarian cancer cells. Methods: The stable ovarian cell lines with miR-194-5p overexpression or silencing IGF1R expression were established by lentivirus infection. ATP generation, glucose uptake, lactate production and extracellular acidification rate (ECAR) assay were used to analyze the effects of aerobic glycolysis in ovarian cancer… More >

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