Guest Editors
Prof. Dr. Anna Maria Lavezzi, University of Milan, Italy. anna.lavezzi@unimi.it
Prof. Dr. Riffat Mehboob, Lahore Medical Research Center, Pakistan. mehboob.riffat@gmail.com
Summary
A biomarker is a measurable indicator that substitutes for and ideally predicts a clinically relevant endpoint or intermediate outcome that is difficult to observe directly. It plays a crucial role in precision medicine, particularly as predictive biomarkers. Clinical biomarkers offer a more cost-effective and efficient alternative to directly measuring the final clinical endpoint, and they have various applications in disease screening, diagnosis, monitoring, and individualized therapeutic interventions. Understanding the pathophysiological relationship between a biomarker and the clinical endpoint is essential. Good biomarkers should be reliable, show little variability, have a significant signal-to-noise ratio, and respond promptly to changes in the condition or its treatment.
Biomarkers are vital for clinical and experimental diagnostics, enabling the detection and quantification of diseases. Rapid detection of disease-specific biomarkers is crucial for early diagnosis and subsequent treatments. Various detection techniques are available for identifying disease biomarkers. In evidence-based medicine, novel molecular biomarkers have the potential to improve disease diagnosis, treatment, and health outcomes while reducing the socio-economic impact of diseases. Biomarkers are extensively used in cancer treatment to monitor disease progression, drug response, relapses, and drug resistance. However, despite extensive research efforts, the identification of biomarkers for early detection, especially in cancer, has been challenging.
This Special Issue aims to gather original research papers, reviews, and commentaries on recent advances in biomarker research in both health and disease. We are particularly interested in new insights into the mechanisms of action underlying physiological and pathological processes and diseases, the discovery of biomarker-associated therapeutic targets, RNA-based therapies associated with biomarkers (including peptide delivery systems), peptide biomarkers (including circulating peptides), and the role of peptides in cell-to-cell communication. The Research Topic seeks to cover innovative research and clinical trends in identifying, characterizing, assessing, and applying molecular biomarkers in different disease conditions.
Areas to be covered in this special issue may include, but are not limited to:
1. Role of peptides in immune-mediated cell death in tumor progression and therapy.
2. Pathophysiologic Mechanisms and Potential Biomarkers
3. Identification and experimental validation of novel molecular, fluid, salivary, tissue, serum, cerebrospinal fluid, spinal fluid, seminal fluid, liquid biopsy biomarkers of different disease conditions such as cancers, neuropathology, neurodegenerative diseases, infectious diseases, pain, psychiatry, cardiovascular
4. Investigation of novel genetic, epigenetic, and biochemical biomarkers
5. Use of biomarkers in human pharmacology
6. Diagnostic and prognostic significance of current and future disease biomarkers
7. Use of combinations of biomarkers and panels of biomarkers for risk prediction, diagnosis, and prognosis of different diseases
We welcome original research articles, reviews, mini-reviews, and opinion articles. All submissions will undergo rigorous peer review, and selected articles will be published in the special issue.
Keywords
neurotransmitters, peptides, immuno-markers, biomarkers, precision medicine
Published Papers
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