Guest Editors
Dr. Vijay Kumar, Department of Interdisciplinary Oncology, Stanley S. Scott Cancer Center, School of Medicine, Louisiana State University Health Science Center (LSUHSC), New Orleans, LA, USA. vij_tox@yahoo.com, vkuma2@lsuhsc.edu
Prof. Giustino Varrassi, Paolo Procacci Foundation, Roma, Italy. giuvarr@gmail.com
Summary
The nervous and immune system are most complicated biological systems in the human body. However, immunology is the one of the least static branches of modern biology among others, and so researchers must always keep asking what’s next. From here, neuroimmunology originates. Fever is a well-known example of neuroimmune interaction, for example endogenous cytokines (humoral immune components), including TNF-α, IL-1α, and IL-6 act locally as well as in the brain to induce neurological symptoms of fever, including appetite loss, muscular pain or bodyache, behavioral changes, and other changes that need direct neuroimmune interaction. However, further advancements in sciences have indicated neuroimmune interactions are crucial to maintain tissue and organ homeostasis, effective immune response during diverse inflammatory diseases, varying form infections to cancers. Hence, this special issue is focused on this emerging area that has much to explore in terms of maintaining homeostasis and disease pathogenesis.
We welcome authors to submit original research, review, and perspective articles focusing on, but not limited to, new findings in the following areas:
1.Neuroimmune interactions necessary to maintain homeostasis
2.Any inflammatory (immune) and neurological changes due to infection, internal changes (hormones, metabolism, microbiota, cancer), etc
3.Neurodegeneration
4.Autoimmunity
5.Chronic pain
6.Other diseases affected by neuroimmune interaction
Keywords
Immunity, Inflammation, Pain, Cytokines, Neurotransmitters, Neurodegeneration, Gut-Microbiota, Cancer, Neurons, Microglia, Astrocytes
Published Papers
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Open Access
REVIEW
Role of necroptosis in spinal cord injury and its therapeutic implications
JIAWEI FU, CHUNSHUAI WU, GUANHUA XU, JINLONG ZHANG, YIQIU LI, CHUNYAN JI, ZHIMING CUI
BIOCELL, Vol.47, No.4, pp. 739-749, 2023, DOI:10.32604/biocell.2023.026881
（This article belongs to this Special Issue:
Neuroimmune Interactions at the Crossroads of Health and Disease)
Abstract Spinal cord injury (SCI), a complex neurological disorder, triggers a series of devastating neuropathological events such as ischemia, oxidative stress, inflammatory events, neuronal apoptosis, and motor dysfunction. However, the classical necrosome, which consists of receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like protein, is believed to control a novel type of programmed cell death called necroptosis, through tumour necrosis factor-alpha/tumour necrosis factor receptor-1 signalling or other stimuli. Several studies reported that necroptosis plays an important role in neural cell damage, release of intracellular pro-inflammatory factors, lysosomal dysfunction and endoplasmic reticulum stress. Recent research indicates that necroptosis is crucial to the…
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