Guest Editors
Prof. Kamil Kuca, Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic.
Dr. Eugenie Nepovimova, Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic
Prof. Rohit Sharma, Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Science, Banaras Hindu University, India
Summary
Neurodegenerative diseases (NDDs) pose a significant challenge to public health and have far-reaching implications for affected individuals and their families. These disorders, which include Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, involve the progressive loss of neurons and lead to severe cognitive and motor impairments. In recent years, a growing body of research has uncovered critical insights into the cellular and molecular underpinnings of NDDs.
This special issue aims to consolidate and showcase cutting-edge research on the cellular mechanisms driving NDDs, shedding light on disease pathogenesis and therapeutic potential. It will encompass a wide range of topics, including, but not limited to:
-Pathological Protein Aggregation: Investigating the molecular basis of protein misfolding and aggregation in NDDs, with a focus on proteins like alpha-synuclein, tau, and amyloid-beta.
-Cellular Dysfunction: Analyzing the impact of NDDs on synaptic and neuronal network function, cytoskeletal abnormalities, aberrant proteostasis, and altered energy homeostasis.
-Genetic and Molecular Factors: Examining the genetic and biochemical pathways that contribute to NDDs, including DNA and RNA defects, inflammation, and oxidative stress.
-Neuroinflammation: Exploring the role of neuroinflammation in Alzheimer's disease and other NDDs, with a focus on mechanisms and clinical applications.
-Gut-Brain Axis: Investigating the influence of the gut microbiota, particularly the role of pathogens like Helicobacter pylori, on NDD pathogenesis.
-Molecular Mechanisms: Delving into the cellular and molecular mechanisms underlying neuroinflammation and disease progression in NDDs, with a specific focus on the role of microglia and astrocytes.
We welcome contributions from researchers, scientists, and experts in the field of neurodegenerative diseases and cell biology. Manuscripts can include original research articles, reviews, and perspectives. This special issue will serve as a valuable resource for the scientific community, consolidating recent advancements and insights in the field of NDDs. By focusing on the intricate cellular biology of these diseases, we hope to facilitate progress towards effective treatments and interventions that will significantly impact the lives of those affected by NDDs.
Keywords
neurodegenerative disorders, protein aggregation, cellular dysfunction, genetic and molecular factors, neuroinflammation, neuroprotection, neurotoxicity, natural products, bioactive compounds, oxidative stress, omics, biomarkers, Parkinson’s disease, Alzheimer’s disease, anti-inflammatory agents
Published Papers
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