Special Issues
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Non-coding RNAs (ncRNAs) in Human Diseases

Submission Deadline: 31 March 2025 View: 154 Submit to Special Issue

Guest Editors

Prof. Alma D. Campos-Parra, Instituto de Salud Pública, Universidad Veracruzana (UV), México.
Prof. Macrina Silva Cazares, Unidad Académica Multidisciplinaria Región Altiplano, Universidad Autónoma de San Luis Potosí (UASLP), México.

Summary

Non-coding RNAs (ncRNAs) are a diverse class of RNA molecules that play crucial regulatory roles in various cellular processes. Their involvement in transcriptional and post-transcriptional regulation, epigenetic modifications, and chromatin remodeling has profound implications for human health and disease. This special issue aims to explore the multifaceted roles of ncRNAs, particularly circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), in the pathogenesis of human diseases, including cancer, neurological disorders, and cardiovascular diseases.

 

Topics may include, but are not limited to:

1. Functional Characterization of ncRNAs: Investigating the regulatory roles of circRNAs and lncRNAs in cellular processes such as proliferation, differentiation, and apoptosis.

2. ncRNAs in Disease Pathogenesis: Examining the aberrant expression and dysregulation of ncRNAs in various diseases and their potential as diagnostic or prognostic markers.

3. Therapeutic Targeting of ncRNAs: Discussing the potential of ncRNAs as therapeutic targets for the development of novel treatment strategies for human diseases.

4. ncRNAs and Epigenetic Regulation: Exploring the role of ncRNAs in epigenetic modifications and chromatin remodeling, and their impact on gene expression and disease development.

 

This special issue will provide a platform for researchers and clinicians to share their latest findings and insights into the complex roles of ncRNAs in human diseases. We invite original research articles, reviews, and perspectives that contribute to advancing our understanding of ncRNA biology and its implications for disease pathology and therapy.


Keywords

non-coding RNA, human disease, epigenetic marker, therapy, pathogenesis, transcriptome

Published Papers


  • Open Access

    REVIEW

    The roles and mechanisms of miRNA in HBV-HCC carcinogenesis: Why no therapeutic agents after 30 years?

    KURT SARTORIUS, BENN SARTORIUS, CHERIE WINKLER, ANIL CHUTURGOON, ANNA KRAMVIS, PING AN, WEIGANG ZHANG, YUNJIE LU
    BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505
    (This article belongs to the Special Issue: Non-coding RNAs (ncRNAs) in Human Diseases)
    Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >

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