Guest Editors
Prof. Dr. Yi Cao, University of South China, Hengyang, China. caoyi39@126.com
Summary
Many nanomaterials (NMs) are widely used in many important areas, which could lead to the direct contact of human beings with NMs. However, the toxicity of NMs is not fully known. The in vitro models allow the screening of toxicity of NMs and mechanism studies, and are widely used in nanotoxicological studies.
The aim of this study is to bring the latest development about in vitro toxicology of NMs. Potential topics include, but not limited to:
· Using in vitro models to screen the toxicity of NMs, with a focus on the role of physicochemical properties of NMs;
· Using in vitro models to investigate the mechanisms, such as oxidative stress, ER stress and autophagy;
· Development of advanced in vitro models to study the toxicity of NMs, such as 3D-based models;
· Using omics-based techniques to systemically evaluate the toxicity of NMs.
Reviews, full-length research papers and short communications are welcome for this special issue.
Keywords
Nanomaterials (NMs), In Vitro Models, 3D Cell Cultures, Toxicology, Mechanisms, Physicochemical Properties, Oxidative Stress, Endoplasmic Reticulum (ER) Stress, Autophagy, Omics Techniques
Published Papers
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Open Access
ARTICLE
IR780 loaded hollow MnO2 nanoparticles for dual-mode imaging and enhanced photodynamic therapy of oral squamous cell carcinoma
WEI PAN, YE HE, MENGDONG HE, FEI WANG, LIHUA QIU
BIOCELL, Vol.46, No.4, pp. 1079-1088, 2022, DOI:10.32604/biocell.2022.016934
（This article belongs to this Special Issue:
Molecular and Cellular Toxicity of Nanomaterials)
Abstract Photodynamic therapy (PDT) has emerged as a novel therapeutic modality for cancer treatment, but its therapeutic efficacy is severely limited by the hypoxic tumor microenvironment (TME). Here we designed an innovative multifunctional nano-platform which consists of a hollow MnO
2 shell and internal photosensitizer IR780. It is not only used for multimodal imaging of oral squamous cell carcinoma (OSCC), but also for adjustment hypoxic TME to enhance cancer treatment. Hollow MnO
2 can promote decomposition of tumor endogenous H
2O
2 to relieve tumor hypoxia, thereby enhancing the effect of photodynamic therapy. Photosensitizer IR780 generates singlet oxygen under laser irradiation to kill tumor cells,…
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