Guest Editors
Prof. Jinxi Wang
Email: jwang@kumc.edu
Affiliation: Department of Orthopedic Surgery and Sports Medicine, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
Homepage:
Research Interests: osteoblast differentiation, biomaterial-carried osteogenic proteins for bone regeneration, pathogenetic mechanisms and novel therapies for osteoarthritis, chondrocyte differentiation and cartilage repair
Prof. Thorsten Kirsch
Email: Thorsten.Kirsch@nyulangone.org
Affiliation: Department of Biomedical Engineering, New York University Tandon School of Engineering; Department of Orthopedic Surgery, New York University Grossman School of Medicine, New York, NY 10016 USA.
Homepage:
Research Interests: joint biology, cartilage, osteoarthritis, extracellular vesicles, annexin, chondrocytes, cartilage repair
Prof. Qiping Zheng
Email:qp_zheng@hotmail.com
Affiliation: Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China
Homepage:
Research Interests: genetics, molecular biology, skeletal development, cancer research
Summary
The field of musculoskeletal biology and disease encompasses a diverse and complex network of cells, tissues, and molecular components involved in the development and maintenance of musculoskeletal tissues as well as pathogenesis and treatment of skeletal disorders. This themed issue aims to highlight the latest research on the molecular and cellular mechanisms of musculoskeletal biology, disease, and regeneration. The major goal of this special issue is to advance our understanding of the mechanisms of skeletal development and related genetic diseases, postnatal and age-related disorders, and regenerative medicine for the musculoskeletal system.
We invite submissions that provide novel insights into the molecular and cellular mechanisms of musculoskeletal development and diseases. Topics of interest include, but are not limited to:
1. Skeletal development:
- Osteoblast differentiation and osteogenesis
- Pathways involved in the regulation of osteoblast function and bone mineralization.
- Chondrocyte differentiation and chondrogenesis
- Regulatory mechanisms of skeletal development: Role of growth factors, cytokines, and extracellular matrix proteins
2. Development of skeletal muscles:
– Developmental process of skeletal muscles
- Structure and function of skeletal muscles
3. Genetic musculoskeletal diseases:
- Molecular basis and genetic mutations associated with skeletal dysplasia (e.g., achondroplasia, osteogenesis imperfecta)
- Genetic predispositions to early-onset osteoarthritis and other degenerative musculoskeletal conditions
- Advances in gene editing technologies (e.g., CRISPR-Cas9) for correcting genetic defects in musculoskeletal diseases
- Interplay between genetic mutations and environmental factors in the progression of musculoskeletal disorders
4. Musculoskeletal disorders:
- Idiopathic osteoarthritis: Biomarkers, pathogenesis, initiation, progression, and novel therapies
- Post-traumatic osteoarthritis: Biological and imaging biomarkers, initiation, progression, and novel therapies
- Rheumatoid arthritis: Mechanisms and novel therapies
- Musculoskeletal aging: Osteoporosis, sarcopenia, etc.
5. Musculoskeletal tissue engineering and regeneration:
- Bone regeneration
- Articular cartilage repair
- Tendon and ligament repair
- Natural biomaterials for musculoskeletal tissue regeneration
- Synthetic biomaterials for musculoskeletal tissue regeneration
- Regulatory mechanisms for musculoskeletal tissue regeneration
6. Translational and clinical research:
- Bridging basic research findings with clinical applications in musculoskeletal biology
- Clinical trials and case studies on new therapies for musculoskeletal disorders
- Discussion on regulatory and ethical considerations in developing novel treatments for musculoskeletal disorders
Keywords
musculoskeletal biology, musculoskeletal disease, biomaterials, bone regeneration, osteoarthritis, chondrocyte differentiation, cartilage repair, ligaments, tissue engineering, regenerative medicine, molecular mechanisms, signaling pathways, orthopedic research, tendon, translational research
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