Guest Editors
Dr. Roberto Cannataro
Email: r.cannataro@gmail.com
Affiliation: Galascreen Laboratories, University of Calabria, Via Savinio, Rende (CS), 87040, Italy
Homepage:
Research Interests: Nutrition, microRNA, Strenght training, epigenetic, nutritional supplements
Dr. Diego A Bonilla
Email: dabonilla@dbss.pro
Affiliation: Research Division, Dynamical Business & Science Society – DBSS International SAS, Bogota, 110111, Colombia
Homepage:
Research Interests: nutrition, nutritional supplements, allostatic load, biochemistry, epigenetics, creatine
Dr. Jorge L petro
Email: jorgelpetro@correo.unicordoba.edu.co
Affiliation: Research Group in Physical Activity, Sports and Health Sciences (GICAFS), University of Cordoba, Monteira, 230002, Colombia
Homepage:
Research Interests: PhysiologyMuscle BiologyCell CultureMolecular Biology, Body Composition
Summary
1. Last year Nobel Prize was awarded to V Ambros and G Ruvkun for their discovery of microRNA; those small sequence of nucleotides (20-25) are gaining lot of attention in the last 15-20 years; first they were thought as waste products; now it is well established that they act as messengers between cells.
2. Every tissue produces and secrete miRNA, and they are found in all body fluids; skeletal muscle possesses a specific pool of microRNA called myomir; they are strongly influenced by physical activity but once in the circulation they could influence other organ’s function, even brain.
3. The main focus on myomir could be:
· Better understand and characterize the already known pool, try to find possible overlapping with others microRNA such the ones related to inflammation
· Consider the circulating myomir, that could be used as biomarker to monitor exercise effectivity, prevent over-training syndrome, allowing the correct effect of allostasis.
· Characterize microRNA in healthy subjects and have a comparison with un-healthy, in different pathological states such as sarcopenia, lipedema, sclerosis, cancer; in this case microRNA could serve as early biomarker, but in the future even as a drug (via exogenous microRNA or antagomir).
· Try to understand how exercise (in different application such as strength training, endurance, mixed and, sport specific), life style, gender, age, nutrition, supplementation could influence myomir profile
3. myomir could represent a novel and unexplored field; not only applied to sports science but even in diagnostic and pharmacological application. There is the need to have more deep study on how they works and how they influences protein synthesis; the more fascinating application is the inter-cellular communication, that could explain, for example, why physical exercise is beneficial non only for muscle itself, but for the whole organism.
Keywords
microRNA, myomir, epigenetic, strength training, inflammation, supercompensation
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