Guest Editors
Prof. Dario Pitocco
Email: dario.pitocco@policlinicogemelli.it
Affiliation: Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy
Homepage:
Research Interests: ADAMTS-13, lower limb percutaneous transluminal angioplasty, thrombotic angiopathies, transcutaneous oximetry, type 2 diabetes mellitus, von Willebrand factor
Prof. Paola Muti
Email: paola.muti@unimi.it
Affiliation: Department of Biomedical, Surgical and Dental Sciences, Università di Milano, 20122 Milan, Italy.
Homepage:
Research Interests: colon cancer, gut microbiome, high-fat diet, metformin, obesity
Dr. Angelo Emilio Claro
Email: angelo.claro@unimi.it
Affiliation: Department of Medical and Surgical Sciences, Diabetes Care Unit, Agostino Gemelli IRCCS University Hospital Foundation, Catholic University of Sacred Heart, 00168, Rome, Italy
Department of Biomedical, Surgical, and Dental Sciences, University of Milan, 20122, Milan, Italy
Homepage: https://expertise.unimi.it/resource/person/175841
Research Interests: inflammation, cytokines, glucagon-like peptide-1 receptor agonists, diabetes mellitus type 2, stress psychological, sleep wake disorders, food addiction
Dr. Clelia Palanza
Email: cleliapalanza@gmail.com
Affiliation: Department of Environmental Biology, University of Rome Sapienza, 00168, Rome, Italy
Research Interests: inflammation, cytokines, glucagon-like peptide-1 receptor agonists, diabetes mellitus type 2, stress psychological, sleep wake disorders, food addiction
Summary
Diabetes, particularly type 2 diabetes, is a major global health concern, with profound implications and relationships with several non-communicable diseases (NCDs) such as cardiovascular diseases, cancers, chronic kidney disease (CKD), psychiatric disorders, and neurodegenerative disorders. Despite the increasing prevalence of diabetes and its association with NCDs, the molecular mechanisms that link these conditions remain not fully understood. This special issue aims to provide a comprehensive exploration of the underlying molecular mechanisms that connect diabetes with NCDs, focusing on how dysregulated metabolic pathways contribute to disease pathogenesis. By assembling cutting-edge research from global experts, this issue seeks to unravel the intricate interplay between diabetes and its associated diseases, shedding light on shared molecular pathways and offering insights into novel therapeutic strategies.
Key areas of focus include but are not limited to:
1. Diabetes and Cardiovascular Diseases:
- Investigating the molecular mechanisms by which diabetes induces vascular damage, inflammation, and atherosclerosis.
- Exploring the roles of oxidative stress, insulin resistance, and advanced glycation end-products (AGEs) in diabetic cardiovascular complications.
2. Diabetes and Cancer:
- Uncovering the mechanisms linking hyperglycemia and insulin resistance with cancer development, particularly through the insulin-like growth factor (IGF) signaling pathway.
- Exploring how metabolic disturbances in diabetes, such as altered lipid metabolism, influence cancer cell proliferation and metastasis.
3. Diabetes and Chronic Kidney Disease (CKD):
- Investigating the molecular pathways that underlie diabetic nephropathy, focusing on inflammation, fibrosis, and glomerular damage.
- Examining how metabolic dysregulation in diabetes accelerates kidney damage and its impact on renal function.
4. Diabetes and Neurodegenerative Diseases:
- Exploring the emerging concept of "type 3 diabetes" in neurodegenerative disorders such as Alzheimer's disease and Parkinson’s disease.
- Understanding how insulin resistance and impaired glucose metabolism in the brain contribute to cognitive decline and neuroinflammation.
5. Genomic and Epigenetic Insights:
- Investigating the genetic predisposition to diabetes and its co-morbidities through genome-wide association studies (GWAS) and epigenetic modifications.
- Exploring how epigenetic changes in response to hyperglycemia influence the development of multiple NCDs.
6. Integrated Multi-Omics Approaches:
- Utilizing multi-omics approaches (genomics, transcriptomics, proteomics, and metabolomics) to investigate shared molecular pathways between diabetes and NCDs.
- Developing integrated disease models to identify common biomarkers and therapeutic targets for diabetes and its associated complications.
7. Clinical and Translational Perspectives:
- Exploring the clinical implications of molecular findings and their potential for personalized medicine in treating diabetes-related NCDs.
- Discussing novel biomarkers and drug targets for the early detection and treatment of both diabetes and associated non-communicable diseases.
We welcome original research articles, comprehensive reviews, and perspectives that investigate the molecular mechanisms underlying the connection between diabetes and non-communicable diseases. This special issue seeks to highlight recent discoveries, offer insights into shared pathophysiological mechanisms, and provide new directions for therapeutic interventions that target these interconnected diseases.
Keywords
diabetes, cardiovascular disease, cancer, chronic kidney disease, neurodegenerative diseases, insulin resistance, molecular mechanisms, genomics, epigenetics, multi-omics, metabolic dysregulation, biomarkers, therapeutic strategies, depression, food addiction, glucagon-like peptide-1 receptor agonists, sleep-wake disorders, stress psychological, dementia
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