Single Cell Technologies and Molecular Mechanisms of Diseases

Submission Deadline: 31 December 2021 (closed)

Guest Editors

Prof. Dr. Youjin Hu, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, CHINA. huyoujin@gzzoc.com

Summary

According to the central dogma, which is also known as DNA-RNA-protein axis, DNA provides the code for RNA, which is translated to produce proteins that fulfill biological functions. Abnormality of gene regulation will result in the diseases. Currently, single cell sequencing technologies are available for transcriptome, genome, epigenome, and proteome profiling, and have become a powerful tool to dissect the genotypic and phenotypic heterogeneity of bulk tissue and promise to deepen understanding of the underlying mechanisms governing both health and disease.

To highlight both technical advances and biological insights into the molecular mechanisms of the diseases, BIOCELL is currently inviting submissions to the special issue on single-cell technologies and molecular mechanisms of diseases. Potential topics include but are not limited to the followings:

• Single cell sequencing technologies

• Single cell multi-omics

• Bioinformatics

• Genetic and epigenetic diseases

• Cancer biology

• Ageing

• Immunological diseases

Keywords

Single-Cell Technologies; Bioinformatics; Genetics; Epigenetics; Diseases

Published Papers

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Open Access

ARTICLE

Effect of Peroxiredoxin 1 on the biological function of airway epithelial cells and epithelial-mesenchymal transition
HUOGEN LIU, YUNDI SHI, XIN WAN, YING LIU, HAILIN SHU, FENGMING HUANG, ZHENBIN GONG, LING GU
BIOCELL, Vol.46, No.12, pp. 2671-2680, 2022, DOI:10.32604/biocell.2022.018054
（This article belongs to the Special Issue: Single Cell Technologies and Molecular Mechanisms of Diseases)
Abstract Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate the effect of PRDX1 on the EMT of airway epithelial cells stimulated with lipopolysaccharide (LPS) and transforming growth factor-beta 1 (TGF-β1). PRDX1 overexpression significantly increased the proliferation and migration of human bronchial epithelial (BEAS-2B) cells, reduced cell apoptosis (p < 0.01), and induced EMT and collagen deposition by upregulating the expression of the matrix metallopeptidase (MMP)2, MMP9, α-smooth muscle actin (α-SMA), N-cadherin, vimentin and twist proteins and inhibiting E-cadherin expression (p < 0.05). PRDX1 overexpression promoted TGF-β1-mediated inhibition of… More >

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ARTICLE

Astaxanthin delayed the pathogenesis of diabetic nephropathy in type 1 diabetic rats
LIANHUAN MA, SHOUPENG LIU, XIAOWEN ZHEN, WEIWEI QIAO, LINA MA, XIAOMIN ZHANG
BIOCELL, Vol.46, No.8, pp. 1911-1916, 2022, DOI:10.32604/biocell.2022.019277
（This article belongs to the Special Issue: Single Cell Technologies and Molecular Mechanisms of Diseases)
Abstract This study was designed to investigate the protective effects of Astaxanthin (AST) in rats with diabetes mellitus (DM) induced by streptozotocin. SD rats were divided into control group (n = 5, only received normal saline), DM group (n = 8) and AST + DM group (n = 8; AST: 50 mg/kg/day). DM rats were induced by intraperitoneal injection of streptozocin (STZ, 65 mg/kg). Blood glucose level and body weight were determined at weeks 0, 2, 4, 6 and 8, respectively. At week 8, kidney function was determined, together with expression of P53 and dynamin-related protein-1 (Drp1) by Western blot analysis… More >

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REVIEW

Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy
ZIQIAN WANG, YAQI LI, DONGYANG WANG, YINGQIANG SHEN
BIOCELL, Vol.46, No.7, pp. 1599-1611, 2022, DOI:10.32604/biocell.2022.018530
（This article belongs to the Special Issue: Single Cell Technologies and Molecular Mechanisms of Diseases)
Abstract Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis have glutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation, Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly, many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, the study of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolic process of ferroptosis, the role… More >

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Single Cell Technologies and Molecular Mechanisms of Diseases

Guest Editors

Summary

Keywords

Published Papers

View

749

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496

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1710

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701

View

2062

Download

954

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1

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