Guest Editors
Prof. Egor Y. Plotnikov
Email: plotnikov@belozersky.msu.ru
Affiliation: A.N. Belozersky Institute of Physical-Chemical Biology, M.V. Lomonosov Moscow State University, 119991, Moscow, Russia
Homepage:
Research Interests: ischemia/reperfusion injury, mitochondrial respiration, oxidative stress, caloric restriction, ketogenic diet, kidney fibrosis, autophagy, mitophagy, renal tubular cells
Summary
Mitochondria are central to cellular energy metabolism and play a pivotal role in regulating oxidative stress and cellular signaling across various physiological and pathological conditions. This special issue aims to explore the intricate mechanisms by which mitochondrial dynamics and oxidative stress contribute to a broad range of diseases and to identify potential therapeutic strategies that could mitigate these effects.
By compiling cutting-edge research from global experts, this issue seeks to deepen our understanding of mitochondrial involvement in different disease contexts. Key areas of focus include but are not limited to:
1. Mitochondrial Dysfunction Across Disease States:
-Investigating the role of mitochondrial dynamics, including fission and fusion, in the pathogenesis of various diseases such as neurodegenerative disorders, cardiovascular diseases, and metabolic syndromes.
-Understanding how mitochondrial dysfunction contributes to cellular damage and disease progression in conditions like cancer, diabetes, and aging-related disorders.
2. Oxidative and Nitrosative Stress in Disease Mechanisms:
-Exploring the impact of oxidative and nitrosative stress on mitochondrial function and its role in disease development.
-Examining the molecular mechanisms underlying oxidative stress-related damage in tissues such as the brain, heart, kidneys, and liver.
3. Protective Signaling Pathways in Mitochondria:
-Identifying key signaling pathways that mediate protective responses in mitochondria under stress conditions across different tissues and organs.
-Evaluating the therapeutic potential of antioxidants, mitochondrial permeability transition pore inhibitors, and other protective agents in mitigating mitochondrial dysfunction.
4. Mitochondria-Targeted Therapies for Disease Management:
-Assessing the efficacy of novel therapeutic strategies aimed at preserving mitochondrial function in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer.
-Highlighting the development of mitochondria-targeted drugs and their potential to prevent or treat mitochondrial dysfunction in diverse disease states.
5. Technological Advances in Mitochondrial Research:
-Showcasing state-of-the-art techniques such as confocal laser scanning microscopy, cell culture methodologies, and flow cytometry in studying mitochondrial dynamics and oxidative stress.
-Discussing the application of these technologies in unraveling the cellular and molecular mechanisms of mitochondrial-related diseases.
Through this special issue, we aim to foster interdisciplinary collaboration and enhance our understanding of how mitochondrial dynamics and oxidative stress influence health and disease across various organ systems. We welcome original research articles, comprehensive reviews, and perspectives that explore the multifaceted roles of mitochondria in the pathogenesis and therapy of different diseases. By highlighting the latest discoveries and challenges in this field, this issue aspires to pave the way for innovative therapeutic strategies and improved outcomes in the treatment of mitochondrial-related diseases.
Keywords
mitochondria, oxidative stress, disease mechanisms, mitochondrial dynamics, therapeutic targeting, neurodegenerative disorders, cardiovascular diseases, cancer, metabolic syndromes, protective signaling
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