Guest Editors
Dr. Kun-Lin Chen, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Email: chenkunlin@jaas.ac.cn.
Prof. Dr. Xing Duan, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, China.
Email: duanxing@zafu.edu.cn.
Summary
Mitochondria are double membrane-bound subcellular organelles present in almost all eukaryotic cells; it generates the basic unit of cellular energy, ATP, through oxidative phosphorylation. Excepting for ATP production, mitochondria are also involved in calcium homeostasis, cell growth and differentiation, apoptosis activation, and cell death. Mitochondrial dysfunction is often linked to metabolic disorders, cancer, and neurodegenerative diseases, including Parkinson’s, Alzheimer’s, and Huntington’s disease. Therefore, maintaining mitochondrial function is prerequisite for the normal cell growth.
To maintain mitochondrial integrity and homeostasis, mitochondria continuously undergo change in number and morphology through the processes of fusion and fission. The balance of mitochondrial fission and fusion is critical for mitochondrial functions, including mitochondrial DNA maintenance, damaged DNA segregation, mitochondrial distribution within the cell, and mitochondrial morphology regulation. Mitochondrial fission and fusion are critical for maintaining mitochondrial function when cells suffer from metabolic and environmental stresses. An imbalance in mitochondrial fission and fusion is associated with several physiological indicators of mitochondrial dysfunction, including reduced mitochondrial membrane potential, respiration, and oxidative phosphorylation and increased mitochondrial ROS generation. Defect in mitochondrial dynamics are linked to many pathological conditions, including cancer, neurodegenerative, and cardiovascular diseases.
This special issue will focus on the contributions of mitochondria to cellular metabolism, as well as mitochondrial dynamics and stress responses and relevance to human diseases and pathologies.
Keywords
Mitochondrial Function, Mitochondrial Dynamics, Oxidative Stress, Cellular Metabolism, Human Disease
Published Papers
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