Guest Editors
Dr. I-Shiang Tzeng, Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan
Summary
Mitochondria, often referred to as the powerhouse of the cell, represent a central procedure in cellular energy metabolism, apoptosis, and various signaling pathways. This proposed special issue aims to comprehend and explore different facets of mitochondria research, covering their structure, function, dynamics, and the implications of mitochondrial dysfunction in various diseases.
The proposed scope includes but is not limited to the following:
1. Mitochondrial-Related Diseases:
Analysis of mitochondrial DNA mutations associated with diseases.
Develop application of animal models to study mitochondrial disorders.
Proteomic and metabolomic studies to uncover molecular changes in diseases linked to mitochondrial dysfunction.
2. Mitochondrial Dynamics and Migration:
Fluorescence-based methods for observing mitochondrial movement and dynamics.
Investigation of the molecular mechanisms regulating mitochondrial fusion and fission.
3. Mitochondria in Cell Death Mechanisms:
Examination of mitochondrial involvement in apoptosis, necrosis, and autophagy.
Functional studies using RNA interference and gene knockout approaches.
4. Mitochondrial Metabolic Regulation:
Assessment of mitochondrial membrane potential and redox status using fluorescent probes.
Genetic editing techniques to modulate the expression of key enzymes in mitochondrial metabolism.
We invite researchers to submit original research articles, reviews, and perspectives that address the outlined topics. The compilation of diverse studies is anticipated to contribute significantly to the current understanding of mitochondria and pave the way for innovative therapeutic strategies targeting mitochondrial dysfunction.
Keywords
mitochondria function; metabolic diseases; therapeutic approaches; mitochondrial dynamic; fluorescence-based methods; cellular energy; mitochondrial metabolism
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