Guest Editors
Dr. Marica Colella
Email: marycolella98@gmail.com
Affiliation: Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy
Homepage:
Research Interests: human microbiota, microbiome, probiotics, infectious diseases, neutraceuticals, metabolites, human pathophysiology
Summary
Recent studies show that the resident microbiota could have a regulatory role in maintaining cardiovascular health and influencing the onset and progression of cardiovascular diseases. This special issue aims to update current knowledge about the molecular mechanisms through which microbial ecosystems impact cardiovascular health, exploring their intricate relationships with host metabolism, inflammation, and immune regulation. By bringing together groundbreaking research from global experts, this issue seeks to advance our understanding of how microbial communities interact with cardiovascular systems, contributing to health and disease. Key areas of focus include but are not limited to:
1. Microbiota and Cardiovascular Homeostasis
- Investigating the mechanisms by which gut and other microbiota contribute to cardiovascular function and homeostasis.
- Exploring the interplay between microbial metabolites (e.g., short-chain fatty acids, trimethylamine-N-oxide) and cardiovascular health.
2. Microbial Metabolites and Disease Progression
- Examining how specific microbial-derived metabolites influence the pathophysiology of cardiovascular diseases, including atherosclerosis, hypertension, and heart failure.
- Deciphering molecular pathways linking microbiota dysbiosis to inflammation and endothelial dysfunction.
3. Microbiota as Biomarkers and Therapeutic Targets
- Developing microbiota-based biomarkers for early detection of cardiovascular disease risk.
- Exploring the potential of prebiotics, probiotics, and microbiota-modulating interventions in cardiovascular therapy.
4. Host-Microbiota Interactions in Cardiovascular Health
- Investigating how diet, lifestyle, and other environmental factors shape host-microbiota interactions and their impact on cardiovascular health.
- Unveiling the molecular signaling pathways mediating host-microbiota crosstalk in cardiac and vascular systems.
5. System Biology Approaches to Cardiovascular Microbiota Research
- Utilizing multi-omics approaches (genomics, metabolomics, transcriptomics) to map host-microbiota networks in cardiovascular health and disease.
- Integrating computational models to predict outcomes of microbiota-based interventions on cardiovascular conditions.
We welcome original research articles, comprehensive reviews, and perspectives that delve into the molecular mechanisms underlying the relationship between microbiota and cardiovascular health. By showcasing innovative research and multidisciplinary approaches, this special issue aims to inspire novel strategies for the prevention, diagnosis, and treatment of cardiovascular diseases through microbiota-targeted approaches, emphasizing the role of how microbiota in the field of tailored medicine.
Keywords
microbiota, cardiovascular health, microbial metabolites, dysbiosis, molecular mechanisms, inflammation, host-microbiota interactions, biomarkers
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