Guest Editors
Prof. Nimanthi Jayathilaka, Department of Chemistry, Faculty of Science, University of Kelaniya, Sri Lanka. njayathi@kln.ac.lk
Summary
MicroRNAs (miRNAs) regulate numerous developmental and physiological processes via transcriptional regulation. These small, non-coding RNAs of 17-25 nucleotides account for 1-3 % of the mammalian genome with approximately 2600 mature miRNAs reported to date. MiRNAs regulate cellular functions and gene expression networks by either repressing translation or subjecting target mRNAs to degradation. Therefore, miRNAs show aberrant expression during the development of infectious and non-infectious diseases and disease progression. These aberrantly expressed miRNAs can be utilized as a diagnosis strategy for diseases. As such, there is high interest in investigating the regulatory functions of miRNA and the role of those miRNAs as biomarkers for disease diagnosis. However, such studies are at times limited to a small subset of miRNAs and are hampered by limited available literature. While the detection of a small number of miRNAs may provide more insight into the molecular mechanisms involved in regulatory gene expression networks and disease progression, high throughput bioinformatics analysis may reveal more robust biomarker candidates for disease diagnosis and prognosis.
This special issue on “MicroRNA as biomarkers for disease diagnosis and progression” invites submission of original papers and review articles that focus on the emerging role of miRNAs in the diagnosis and prognosis of infectious and non-infectious diseases such as viral and bacterial infections, diabetes, cardiovascular diseases, neuromuscular disorders, and cancer using biological and computational analysis as well as clinical investigations.
Areas of interest include, but are not limited to:
1) MiRNAs as biomarkers in the development of infectious or non-infectious diseases.
2) MiRNAs as biomarkers for disease diagnosis in infectious or non-infectious diseases.
3) MiRNAs as biomarkers for the prognosis of infectious or non-infectious diseases.
4) MiRNAs in disease progression in infectious or non-infectious diseases.
5) Molecular mechanism of miRNAs in developing and progressing infectious or non-infectious diseases.
6) Molecular mechanism of miRNAs in the severity of infection or disease progression in non-infectious diseases.
7) Bioinformatic analysis of miRNAs in diagnosis and prognosis of infectious or non-infectious diseases.
8) Systemic review and meta-analysis of miRNAs in infectious and non-infectious disease diagnosis and prognosis
Keywords
microRNA, Biomarker, Diagnosis, Prognosis, Infectious Diseases, Non-Infectious Diseases
Published Papers
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