Guest Editors
Prof. Dr. Giuseppe Caruso
Email: forgiuseppecaruso@gmail.com; giuseppe.caruso@unicamillus.org
Affiliation: Departmental Faculty of Medicine, UniCamillus—Saint Camillus International University of Health and Medical Sciences, Rome, Italy
Homepage:
Research Interests: carnosine, natural products, macrophages, microglia, Alzheimer’s disease, oxidative stress, neuroinflammation, energy metabolism, pharmacology
Prof. Dr. Giacomo Lazzarino
Email: giacomo.lazzarino@unicamillus.org
Affiliation: Departmental Faculty of Medicine, UniCamillus—Saint Camillus International University of Health and Medical Sciences, Rome, Italy
Homepage:
Research Interests: traumatic brain injury, oxidative stress, energy metabolism, mitochondrial dysfunction, acute and chronic neurodegenerations, biochemistry
Dr. Giuseppe Carota
Email: giuseppe-carota@outlook.it
Affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Italy
Research Interests: oxidative stress, inflammation, natural products, toxicology, antioxidant pathways, biochemistry
Summary
Macrophages and microglia are pivotal players in the progression of systemic and neurodegenerative diseases, linking immune response to inflammation, energy metabolism, and oxidative stress. This special issue aims to delve into the molecular mechanisms underlying the dysregulation of these cells in systemic and neurodegenerative diseases, with a particular focus on identifying new therapeutic targets exerting neuroprotection.
By bringing together innovative research from leading experts, this issue seeks to shed more light on how macrophage and microglia activities intersect with disease pathogenesis and highlight promising strategies for therapeutic intervention. Key areas of focus include, but are not limited to:
1. Macrophages and Microglia Dysfunction in Systemic and Neurodegenerative Diseases:
-Investigating the molecular pathways that drive macrophages and microglia dysfunction in conditions like cardiovascular diseases, Alzheimer’s, Parkinson’s, and multiple sclerosis.
-Understanding how the aberrant activation of these cells contributes to neuronal damage and disease progression.
2. Energy Metabolism and Neuroprotection:
-Exploring the role of macrophages and microglia metabolism in pathological conditions, focusing on energy deficits and metabolic reprogramming.
-Examining how targeting metabolic pathways in these cells can offer neuroprotective effects.
3. Oxidative Stress and Cellular Damage:
-Investigating the interplay between oxidative stress and macrophages/microglia dysfunction in neurodegeneration.
-Highlighting novel molecular mechanisms by which oxidative stress exacerbates cellular damage in systemic and neurodegenerative diseases.
4. Pharmacological Target Discovery:
-Identifying new pharmacological targets within macrophage and microglia pathways for therapeutic development.
-Focusing on innovative approaches allowing the modulation of immune cell function and promotion of neuronal survival.
5. Natural Molecules and Neuroprotective Strategies:
-Highlighting research on natural molecules and their potential to regulate macrophages/microglia activity and provide neuroprotection.
-Discussing advances in in vitro models for drug development, emphasizing the role of natural compounds.
Through this special issue, we aim to foster a deeper understanding of how macrophages and microglia dysfunction contributes to neurodegenerative disease mechanisms. We invite original research articles, comprehensive reviews, and perspectives that explore the multifaceted roles of these immune cells in disease pathology and therapeutic development. Critical reviews, discussing conflicting literature data, are also well accepted. By presenting the latest discoveries and technological advancements, this issue seeks to pave the way for novel neuroprotective strategies and therapeutic targets in the treatment of systemic and neurodegenerative diseases.
Keywords
macrophages, microglia, neurodegeneration, neuroinflammation, oxidative and nitrosative stress, energy metabolism, neuroprotection, therapeutic targets, natural molecules
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