Guest Editors
Dr. Weiqi He, Cambridge-Su Genomic Resource Center, Suzhou Medical College of Soochow University, China.
Dr. Le Shen, Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, USA
Summary
The inner lining of the intestine is composed of a singular layer of epithelial cells. Sustained renewal of these cells is orchestrated by the continual proliferation of stem cells located at the crypt's base. These epithelial cells collectively form a vital barrier, safeguarding the internal environment of the body against external agents and preventing the onset of inflammation. Crucially, the persistence of epithelial cells and the proper functioning of the mucosal barrier lie at the heart of the pathogenesis of intestinal disorders, including inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CA-CRC).
In this special edition, we extend a warm invitation for the submission of manuscripts that delve into the intricacies of intestinal stem cell biology, epithelial regeneration, and the functional aspects of the epithelial barrier in both healthy and diseased states.
We encourage contributions covering a broad spectrum of topics, including but not limited to:
• Intestinal stem cells
• Intestinal organoids
• Epithelial barrier function
• Epithelial cell death
• Mucosal immunology
• Inflammatory bowel disease
• Colitis-associated colorectal cancer
• Colorectal cancer
• Gut microbiota
• Circadian clock and gut homeostasis
Authors are invited to explore these areas and contribute valuable insights to further our understanding of intestinal health and disease.
Keywords
intestinal stem cell, barrier function, inflammatory bowel disease, colitis, colorectal cancer, circadian clock, organoids
Published Papers
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