Guest Editors
Prof. Alexander N. Orekhov
Email: alexandernikolaevichorekhov@gmail.com
Affiliation: Faculty of Biology and Biotechnology, National Research University Higher School of Economics, 33, Profsoyuznaya Street, Building 4, 117418 Moscow, Russia
Homepage:
Research Interests: atherogenicity, atherosclerosis, inflammation, innate immunity, modified low-density lipoprotein, transcriptome, cytokine, epigenetics
Dr. Mikhail A. Popov
Email: popovcardio88@mail.ru
Affiliation: Department of Cardiac Surgery in M. F. Vladimirskiy Moscow Regional Research Clinical Institute, 129110 Moscow, Russia
Homepage:
Research Interests: atherosclerosis, ischemic heart disease, lipids and inflammation, heart failure, dysfunctional HDL, genome HDL
Summary
The Special Issue defines lipids in their broadest sense, including various classes and types of lipids and lipid-containing particles, such as triglycerides, Lp(a), PCSK9, apoCIII, cellular and tissue lipid metabolism, lipid transport, and more. Review and research articles, as well as methodological papers that summarize and investigate the role of lipids in various physiological processes, pathological conditions, and diseases, are highly encouraged.
Lipids and inflammation are closely interconnected. Lipid accumulation and inflammatory responses represent two interlinked aspects of many normal and pathological processes. Current knowledge highlights the role of lipid-induced activation of innate and adaptive immunity in chronic inflammation, providing insights into the mechanisms underlying various pathologies. This Special Issue focuses on recent progress in genetic studies, drug discovery, and drug applications in diseases. In recent years, significant advances in genetic research and the growing pool of available data have enabled the discovery of molecular mechanisms underlying several chronic human pathologies, investigations into genetic predispositions to various disorders, and the identification of numerous potential therapeutic targets. Progress in these areas has led to a number of preclinical and clinical trials, which have gathered crucial data on the safety and efficacy of new drugs. Research articles have documented numerous successful examples of drug and gene therapy development and application for cardiovascular diseases, cancer, and other human pathologies. Furthermore, a considerable amount of data has emerged from clinical applications and molecular studies of traditional medicines.
The Special Issue aims to translate the results of basic research into practical disease management strategies. In particular, the focus is on atherosclerosis. Extra- and intracellular lipid deposition, predominantly cholesteryl esters in the arterial intima, represents one of the earliest manifestations of atherosclerosis. The formation of lipid-laden foam cells is recognized as a key trigger in the pathogenesis of atherosclerosis. Low-density lipoprotein (LDL) circulating in human blood serves as the primary source of lipids accumulating in arterial cells. For this accumulation to occur, LDL particles must undergo chemical modification. Studies on modified LDL aim to identify the fundamental modifications that render it atherogenic.
Large-scale epidemiological studies have firmly established the association between low plasma levels of high-density lipoprotein (HDL) and an elevated risk of cardiovascular disease. This relationship is believed to reflect HDL’s key biological function, which involves reverse cholesterol transport from the arterial wall to the liver for subsequent excretion from the body. However, systemic and vascular inflammation may convert HDL into a dysfunctional form with impaired anti-atherogenic effects. A loss of anti-inflammatory and antioxidative proteins, possibly combined with the acquisition of proinflammatory proteins, is thought to play a significant role in rendering HDL dysfunctional.
This Special Issue will encompass basic, translational, clinical, and applied research in these areas. Original research or review papers are warmly welcomed.
Keywords
anti-inflammatory action, apoCIII, atherosclerosis, cholesterol cholesteryl esters, diagnostics, disease, dysfunctional HDL, genome HDL, high-density lipoprotein, inflammation, LDL, lipid-containing particles, low-density lipoprotein, Lp(a), metabolism, modified LDL, molecular genetics, mutations, native LDL, pathology, PCSK9, reserve cholesterol transport, therapy, transcriptome, transport, triglycerides
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